Skeletal muscle mass, function, and repair capacity all progressively decline with aging,
restricting mobility, voluntary function, and quality of life. Skeletal muscle repair is facilitated …

A highly conserved signaling pathway involving insulin-like growth factor 1 (IGF1), and a
cascade of intracellular components that mediate its effects, plays a major role in the …

Integrins are cell surface transmembrane receptors that recognize and bind to extracellular
matrix proteins and counter receptors. Binding of activated integrins to their ligands induces …

Tissue mechanics provide an important context for tissue growth, maintenance and function.
On the level of organs, external mechanical forces largely influence the control of tissue …

The extracellular matrix (ECM) is a highly-dynamic compartment that undergoes remodeling
as a result of injury and repair. Over the past decade, mounting evidence in humans and …

Basement membranes are sheet-like cell-adherent extracellular matrices that serve as cell
substrata and solidphase agonists, contributing to tissue organization, stability and …

The α7β1-integrin is a transmembrane adhesion protein that connects laminin in the
extracellular matrix (ECM) with actin in skeletal muscle fibers. The α7β1-integrin is highly …

Cells recognize and respond to their extracellular environment through transmembrane
receptors such as integrins, which physically connect the extracellular matrix to the …

Integrin-linked kinase (ILK) is a multifunctional intracellular effector of cell-matrix interactions
and regulates many cellular processes, including growth, proliferation, survival …

Dynamic interactions of cells with their environment regulate multiple aspects of tissue
morphogenesis and function. Integrins are the major class of cell surface receptors that …