Preclinical models of medication-related osteonecrosis of the jaw (MRONJ)

JI Aguirre, EJ Castillo, DB Kimmel - Bone, 2021 - Elsevier
Medication-related osteonecrosis of the jaw (MRONJ) is a potentially severe adverse event
affecting patients with cancer and patients with osteoporosis who have been treated with …

Medication-Related Osteonecrosis: Why the Jawbone?

S Kuehn, R Scariot, M Elsalanty - Dentistry Journal, 2023 - mdpi.com
Medication-related osteonecrosis of the jaw (MRONJ) has emerged as a complication of anti-
resorptive medications. Despite its low incidence rate, this problem has gained attention in …

Zoledronic acid–related osteonecrosis of the jaws. Experimental model with dental extractions in rats

P Barba-Recreo, M García-Arranz, L Yébenes… - Journal of Cranio …, 2014 - Elsevier
Introduction Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a pathologic
condition of increasing frequency, with a poorly understood pathophysiology and which can …

Evaluation of the therapeutic effects of conditioned media from mesenchymal stem cells in a rat bisphosphonate-related osteonecrosis of the jaw-like model

K Ogata, W Katagiri, M Osugi, T Kawai, Y Sugimura… - Bone, 2015 - Elsevier
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is defined as an exposed
necrotic bone in the oral cavity that does not heal after appropriate intervention for> 8 weeks …

Effect of Local vs. Systemic Bisphosphonate Delivery on Dental Implant Fixation in a Model of Osteonecrosis of the Jaw

J Abtahi, F Agholme, O Sandberg… - Journal of dental …, 2013 - journals.sagepub.com
Locally applied bisphosphonates may improve the fixation of metal implants in bone.
However, systemic bisphosphonate treatment is associated with a risk of osteonecrosis of …

Effect of different doses of zoledronic acid in establishing of bisphosphonate-related osteonecrosis

PG de Barros Silva, AECF Junior, CR Teófilo… - Archives of oral …, 2015 - Elsevier
Objectives To establish osteonecrosis of the jaws in rats treated with different doses of
zoledronic acid (ZA). Methods Male Wistar rats (n= 6–7) received three consecutive weekly …

The effects of adjunctive parathyroid hormone injection on bisphosphonate-related osteonecrosis of the jaws: an animal study

EH Dayisoylu, FÇ Şenel, C Üngör, E Tosun… - International journal of …, 2013 - Elsevier
Bisphosphonate (BP)-related osteonecrosis of the jaw (BRONJ) is a serious and challenging
complication of chronic BP uptake in patients with osteoporosis who require management of …

Pathogenesis of medication-related osteonecrosis of the jaw: a comparative study of in vivo and in vitro trials

H Holtmann, J Lommen, NR Kübler… - Journal of …, 2018 - journals.sagepub.com
Objective This study was performed to determine whether the results of prevailing in vivo
and in vitro studies offer a reliable model for investigation of medication-related …

Site specific effects of zoledronic acid during tibial and mandibular fracture repair

YY Yu, S Lieu, D Hu, T Miclau, C Colnot - PloS one, 2012 - journals.plos.org
Numerous factors can affect skeletal regeneration, including the extent of bone injury,
mechanical loading, inflammation and exogenous molecules. Bisphosphonates are …

Perioperative antibiotic regimen in rats treated with pamidronate plus dexamethasone and subjected to dental extraction: a study of the changes in the jaws

P López-Jornet, F Camacho-Alonso… - Journal of Oral and …, 2011 - Elsevier
PURPOSE: Osteonecrosis of the jaws is a well-known condition associated with long-term
bisphosphonate use. This study analyzed the prophylactic effect of antibiotic treatment in …