Decades of research indicate mitochondria from Alzheimer's disease (AD) patients differ
from those of non-AD individuals. Initial studies revealed structural differences, and …

Although the pathogenesis of neurodegenerative diseases is still widely unclear, various
mechanisms have been proposed and several pieces of evidence are supportive for an …

Ten years ago we first proposed the Alzheimer's disease (AD) mitochondrial cascade
hypothesis. This hypothesis maintains that gene inheritance defines an individual's baseline …

Imaging has played a variety of roles in the study of Alzheimer disease (AD) over the past
four decades. Initially, computed tomography (CT) and then magnetic resonance imaging …

Objective: This observational multimodality brain imaging study investigates emergence of
endophenotypes of late-onset Alzheimer disease (AD) risk during endocrine transition states …

Rationale: Recent evidence suggests that obstructive sleep apnea (OSA) may be a risk
factor for developing mild cognitive impairment and Alzheimer's disease. However, how …

Objective To examine in a 3-year brain imaging study the effects of higher vs lower
adherence to a Mediterranean-style diet (MeDi) on Alzheimer disease (AD) biomarker …

Two thirds of all persons with late-onset Alzheimer's disease (AD) are women. Identification
of sex-based molecular mechanisms underpinning the female-based prevalence of AD …

We first proposed the mitochondrial cascade hypothesis of sporadic Alzheimer's disease
(AD) in 2004. Our core assumptions were a person's genes determine baseline …

Recent developments of PET amyloid ligands have made it possible to visualize the
presence of Aβ deposition in the brain of living participants and to assess the consequences …