In addition to being a component of innate immunity and an ancient defense mechanism
against invading pathogens, complement activation also participates in the adaptive …

High-grade serous ovarian cancer, also known as high-grade serous carcinoma (HGSC), is
the most common and deadliest type of ovarian cancer. HGSC appears to arise from the …

There have been major advances in our understanding of the cellular and molecular biology
of the human malignancies that are collectively referred to as ovarian cancer. At a recent …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

Ovarian cancer is responsible for 4% of deaths from cancer in women. Treatment comprises
a combination of surgery and chemotherapy, but patients typically experience disease …

Ovarian carcinomas are a heterogeneous group of neoplasms and are traditionally
subclassified based on type and degree of differentiation. Although current clinical …

Although ovarian cancer is the most lethal gynecologic malignancy in women, little is known
about how the cancer initiates and metastasizes. In the last decade, new evidence has …

The ovarian reserve represents the stock of quiescent primordial follicles in the ovary which
is gradually depleted during a woman's reproductive lifespan, resulting in menopause …

We characterized the initiation and evolution of the immune response against a new
inducible p53-dependent model of aggressive ovarian carcinoma that recapitulates the …

The recent identification of “side population”(SP) cells in a number of unrelated human
cancers and their normal tissue sources has renewed interest in the hypothesis that cancers …