PEGylation is a versatile drug delivery technique that presents a particularly wide range of
conjugation chemistry and polymer structure. The conjugated protein can be tuned to …

Glycation of milk proteins and peptides can be achieved by Maillard-induced conjugation of
reducing carbohydrates with the available amino groups of proteins/peptides during the …

Chromatographic monoliths have already penetrated in many different areas of separation
sciences. This is due to their properties, especially advantageous for fast separation and …

We have developed a fluoro-microbead guiding chip (FMGC) to perform an optical
immunoassay of cardiac troponin I (cTnI). The plasma marker protein cTnI is the currently …

The covalent attachment of polyethylene glycol (PEG) to therapeutical proteins is an
important route to develop biobetters for biomedical, biotech and pharmaceutical industries …

L-asparaginase (ASNase) from Escherichia coli is currently used in some countries in its
PEGylated form (ONCASPAR, pegaspargase) to treat acute lymphoblastic leukemia (ALL) …

PEGylation is a well-known process in the bio-pharmaceutical industry mainly due to its
great performance in increasing blood circulation half-life of peptides and proteins for health …

Covalent attachment of PEG to proteins, known as PEGylation, is currently one of the main
approaches for improving the pharmacokinetics of biopharmaceuticals. However, the …

The chromatographic methods used for the purification of PEGylated proteins are mainly
Size Exclusion (SEC) and Ion Exchange Chromatography (IEX). Although the PEGylation …

We discuss the use of a laterally-fed membrane chromatography (or LFMC) device for single-
step purification of mono-PEGylated lysozyme. Recent studies have shown such LFMC …