The inhibitor of apoptosis proteins (IAPs) are a family of antiapoptotic proteins that bind and
inhibit caspases 3, 7, and/or 9, but not caspase 8. Growing evidence also indicates that IAPs …

The capacity for multiparametric measurement of large cell populations rapidly and
accurately offered by cytometry has made this methodology indispensable in studies of cell …

Increased phosphorylation of myosin light chain (MLC) is necessary for the dynamic
membrane blebbing that is observed at the onset of apoptosis. Here we identify ROCK I, an …

purpose. The lipofuscin fluorophore A2E has been shown to mediate blue light–induced
damage to retinal pigment epithelial (RPE) cells. The purpose of this study was to evaluate …

Apoptosis induced by T cell receptor (TCR) triggering in T lymphocytes involves activation of
cysteine proteases of the caspase family through their proteolytic processing. Caspase-3 …

Fat distribution varies among individuals with similar body fat content. Innate differences in
adipose cell characteristics may contribute because lipid accumulation and lipogenic …

To the Editor: Chemoprevention can prevent second primary cancers in patients with cancer,
1 but the effect of secondary cancer prevention on absolute survival has not been …

We have established an in vitro culture model of cellular aging in which antigen-specific T
cells are stimulated repeatedly to divide until they reach the irreversible state of growth …

Fat mass, adipocyte size and metabolic responsiveness, and preadipocyte differentiation
decrease between middle and old age. We show that expression of CCAAT/enhancer …

Granzyme B (grB) is a serine proteinase released by cytotoxic lymphocytes (CLs) to kill
abnormal cells. GrB-mediated apoptotic pathways are conserved in nucleated cells; hence …