Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response

J Mandal, P Mandal, TL Wang, IM Shih - Journal of biomedical science, 2022 - Springer
Chromatin remodeling is an essential cellular process for organizing chromatin structure into
either open or close configuration at specific chromatin locations by orchestrating and …

The emerging roles of ARID1A in tumor suppression

RC Wu, TL Wang, IM Shih - Cancer biology & therapy, 2014 - Taylor & Francis
ARID1A has emerged as a tumor suppressor gene, which is mutated in a broad spectrum of
cancers, especially in those arising from ectopic or eutopic endometrium. As a subunit of …

SWI/SNF chromatin remodeling complexes and cancer

JA Biegel, TM Busse… - American Journal of …, 2014 - Wiley Online Library
The identification of mutations and deletions in the SMARCB1 locus in chromosome band
22q11. 2 in pediatric rhabdoid tumors provided the first evidence for the involvement of the …

ARID1A expression loss in gastric cancer: pathway-dependent roles with and without Epstein–Barr virus infection and microsatellite instability

H Abe, D Maeda, R Hino, Y Otake, M Isogai, AS Ushiku… - Virchows Archiv, 2012 - Springer
The AT-rich interactive domain 1A gene (ARID1A), which encodes one of the subunits in the
Switch/Sucrose Nonfermentable chromatin remodeling complex, carries mutations and is …

[HTML][HTML] Prognostic role and implications of mutation status of tumor suppressor gene ARID1A in cancer: a systematic review and meta-analysis

C Luchini, N Veronese, M Solmi, H Cho, JH Kim… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Loss of the tumor suppressor gene AT-rich interactive domain-containing protein 1A
(ARID1A) has been demonstrated in several cancers, but its prognostic role is unknown. We …

Recent advances in the ARID family: focusing on roles in human cancer

C Lin, W Song, X Bi, J Zhao, Z Huang, Z Li… - OncoTargets and …, 2014 - Taylor & Francis
The human AT-rich interaction domain (ARID) family contains seven subfamilies and 15
members characterized by having an ARID. Members of the ARID family have the ability to …

MiR-31 is an independent prognostic factor and functions as an oncomir in cervical cancer via targeting ARID1A

N Wang, Y Zhou, L Zheng, H Li - Gynecologic oncology, 2014 - Elsevier
Objectives MicroRNAs (miRNAs) play important roles in tumor development and
progression. The purposes of this study were to investigate the role of miR-31 in cervical …

Diagnostic significance and prognostic role of the ARID1A gene in cancer outcomes

EN Pavlidou, V Balis - World Academy of Sciences …, 2020 - spandidos-publications.com
Mutations of the ARID1A gene, which encodes the basic directional subunit of SWI/SNF
chromatin remodeling complexes, were detected in the middle of the last decade in several …

[HTML][HTML] ARID1A loss is prevalent in endometrial hyperplasia with atypia and low-grade endometrioid carcinomas

HMJ Werner, A Berg, E Wik, E Birkeland, C Krakstad… - Modern Pathology, 2013 - Elsevier
Abstract ARID1A (AT-rich interactive domain 1A) has recently been identified as a tumor
suppressor gene in various, predominantly gynecological cancers. We wanted to investigate …

Loss of ARID1A, ARID1B, and ARID2 expression during progression of gastric cancer

T Aso, H Uozaki, S Morita, A Kumagai… - Anticancer …, 2015 - ar.iiarjournals.org
Background/Aim: Gastric cancer is a common cancer worldwide. Chromatin remodeling
complexes have emerged as tumor suppressors and include AT-rich interaction domain …