Fibrosis is the abnormal deposition of extracellular matrix, which can lead to organ
dysfunction, morbidity, and death. The disease burden caused by fibrosis is substantial, and …

Tissue inhibitors of metalloproteinases (TIMPs), which inhibit matrix metalloproteinases
(MMPs) as well as the closely related, a disintegrin and metalloproteinases (ADAMs) and …

Repair following injury involves a range of processes–such as re-epithelialization, scar
formation, angiogenesis, inflammation, and more–that function, often together, to restore …

Skin aging is a complex process, and alterations in human skin due to aging have distinct
characteristic as compared to other organs. The aging of dermal cells and the biological …

Previously, we have shown that the adipocyte-specific nuclear form of sterol regulatory
element-binding protein-1c (nSREBP-1c) transgenic mice spontaneously developed hepatic …

Background Macrophages play important roles during wound healing, and delayed healing
in diabetics is associated with sustained inflammation. M1 type macrophage is recognized to …

Keloids are fibroproliferative skin disorder caused by abnormal healing of injured or irritated
skin and are characterized by excessive extracellular matrix (ECM) synthesis and …

Fibrosis is a common pathological feature of organ diseases resulting from excessive
production of extracellular matrix, which accounts for significant morbidity and mortality …

Background Hypertrophic scars (HS) generally occur after injury to the deep layers of the
dermis, resulting in functional deficiency for patients. Growing evidence has been identified …

Synovial fibrosis is often found in OA, contributing heavily to joint pain and joint stiffness, the
main symptoms of OA. At this moment the underlying mechanism of OA-related synovial …