Background Widely used for acute pain management, the clinical benefit from perioperative
use of gabapentinoids is uncertain. The aim of this systematic review was to assess the …

The development of chronic pain is considered a major complication after surgery. Basic
science research in animal models helps us understand the transition from acute to chronic …

Background Chronic postsurgical pain can severely impair patient health and quality of life.
This systematic review update evaluated the effectiveness of systemic drugs to prevent …

Enhanced recovery after surgery (ERAS) protocols produce significant clinical and
economic benefits in a range of surgical subspecialties. There is a long tradition of applying …

Introduction The aim of this systematic review was to document efficacy, safety and quality of
evidence of analgesic interventions after total knee arthroplasty (TKA). Methods This …

Worldwide, 80% of patients who undergo surgery receive opioid analgesics as the
fundamental agent for pain relief. However, the irrational use of opioids leads to excessive …

Successes using enhanced recovery after surgery (ERAS) protocols for total hip arthroplasty
(THA) are increasingly being reported. As in other surgical subspecialties, ERAS for THA …

Background Oral multimodal analgesia for hip and knee arthroplasty is increasingly used as
part of enhanced recovery protocols designed to minimize early postoperative pain and to …

1. Background Chronic postsurgical pain (CPSP) is defined as pain persisting for more than
2 months after surgery. 32 Its reported that incidence varies from 10% to 50%. 33 A high …

Background Duloxetine is effective for chronic musculoskeletal and neuropathic pain, but
there are insufficient data to recommend the use of antidepressants for postoperative pain …