Genistein: an integrative overview of its mode of action, pharmacological properties, and health benefits

J Sharifi-Rad, C Quispe, M Imran, A Rauf… - Oxidative medicine …, 2021 - Wiley Online Library
Genistein is an isoflavone first isolated from the brooming plant Dyer's Genista tinctoria L.
and is widely distributed in the Fabaceae family. As an isoflavone, mammalian genistein …

Environmental factors affecting thyroid-stimulating hormone and thyroid hormone levels

M Babić Leko, I Gunjača, N Pleić… - International journal of …, 2021 - mdpi.com
Thyroid hormones are necessary for the normal functioning of physiological systems.
Therefore, knowledge of any factor (whether genetic, environmental or intrinsic) that alters …

Molecular mechanisms of action of genistein in cancer: Recent advances

HS Tuli, MJ Tuorkey, F Thakral, K Sak… - Frontiers in …, 2019 - frontiersin.org
Background: Genistein is one among the several other known isoflavones that is found in
different soybeans and soy products. The chemical name of genistein is 4′, 5, 7 …

Natural polyphenols for prevention and treatment of cancer

Y Zhou, J Zheng, Y Li, DP Xu, S Li, YM Chen, HB Li - Nutrients, 2016 - mdpi.com
There is much epidemiological evidence that a diet rich in fruits and vegetables could lower
the risk of certain cancers. The effect has been attributed, in part, to natural polyphenols …

Flavonoids as prospective compounds for anti-cancer therapy

D Ravishankar, AK Rajora, F Greco… - The international journal …, 2013 - Elsevier
Flavonoids, which are polyphenolic compounds, are a class of plant secondary metabolites
possessing a broad spectrum of pharmacological activity including anti-cancer activities …

Recent advance of small-molecule drugs for clinical treatment of osteoporosis: A review

JY Zhang, YH Zhong, LM Chen, XL Zhuo… - European journal of …, 2023 - Elsevier
Osteoporosis is a metabolic bone disorder typified by a reduction in bone mass and
structural degradation of bone tissue, leading to heightened fragility and vulnerability to …

Dietary phenolic compounds as anticancer natural drugs: recent update on molecular mechanisms and clinical trials

S Bakrim, N El Omari, N El Hachlafi, Y Bakri, LH Lee… - Foods, 2022 - mdpi.com
Given the stochastic complexity of cancer diseases, the development of chemotherapeutic
drugs is almost limited by problems of selectivity and side effects. Furthermore, an …

Soy isoflavones and prostate cancer: a review of molecular mechanisms

AM Mahmoud, W Yang, MC Bosland - The Journal of steroid biochemistry …, 2014 - Elsevier
Soy isoflavones are dietary components for which an association has been demonstrated
with reduced risk of prostate cancer (PCa) in Asian populations. However, the exact …

[HTML][HTML] Polyphenols and their effects on diabetes management: A review

N Aryaeian, SK Sedehi, T Arablou - … of the Islamic Republic of Iran, 2017 - ncbi.nlm.nih.gov
Background: Type 2 diabetes is a growing public health problem and is associated with
increased morbidity and mortality. The worldwide prevalence of type 2 diabetes is rising …

Plants as a source of anticancer agents: From bench to bedside

WH Talib, S Daoud, AI Mahmod, RA Hamed, D Awajan… - Molecules, 2022 - mdpi.com
Cancer is the second leading cause of death after cardiovascular diseases. Conventional
anticancer therapies are associated with lack of selectivity and serious side effects. Cancer …