Disease mechanisms and gene therapy for Usher syndrome

GGS Géléoc, A El-Amraoui - Hearing research, 2020 - Elsevier
Usher syndrome (USH) is a major cause of deaf-blindness in humans, affecting∼ 400 000
patients worldwide. Three clinical subtypes, USH1-3, have been defined, with 10 USH …

Perception and coding of interaural time differences with bilateral cochlear implants

B Laback, K Egger, P Majdak - Hearing Research, 2015 - Elsevier
Bilateral cochlear implantation is increasingly becoming the standard in the clinical
treatment of bilateral deafness. The main motivation is to provide users of bilateral cochlear …

Effect of mismatched place-of-stimulation on binaural fusion and lateralization in bilateral cochlear-implant users

A Kan, C Stoelb, RY Litovsky… - The Journal of the …, 2013 - pubs.aip.org
Bilateral cochlear implants (CIs) have provided some success in improving spatial hearing
abilities to patients, but with large variability in performance. One reason for the variability is …

Having two ears facilitates the perceptual separation of concurrent talkers for bilateral and single-sided deaf cochlear implantees

JGW Bernstein, MJ Goupell, GI Schuchman… - Ear and …, 2016 - journals.lww.com
Objectives: Listening to speech with multiple competing talkers requires the perceptual
separation of the target voice from the interfering background. Normal-hearing listeners are …

The benefit of head orientation to speech intelligibility in noise

JA Grange, JF Culling - The Journal of the Acoustical Society of …, 2016 - pubs.aip.org
Spatial release from masking is traditionally measured with speech in front. The effect of
head-orientation with respect to the speech direction has rarely been studied. Speech …

The effect of interaural mismatches on contralateral unmasking with single-sided vocoders

JM Wess, DS Brungart, JGW Bernstein - Ear and Hearing, 2017 - journals.lww.com
Objectives: Cochlear-implant (CI) users with single-sided deafness (SSD)—that is, one
normal-hearing (NH) ear and one CI ear—can obtain some unmasking benefits when a …

Benefits of simultaneous bilateral cochlear implantation on verbal reasoning skills in prelingually deaf children

E Jacobs, A Goedegebure, C Smits… - Research in …, 2016 - Elsevier
Background Impaired auditory speech perception abilities in deaf children with hearing aids
compromised their verbal intelligence enormously. The availability of unilateral cochlear …

Mechanisms of localization and speech perception with colocated and spatially separated noise and speech maskers under single-sided deafness with a cochlear …

C Dirks, PB Nelson, DP Sladen, AJ Oxenham - Ear and Hearing, 2019 - journals.lww.com
Objectives: This study tested listeners with a cochlear implant (CI) in one ear and acoustic
hearing in the other ear, to assess their ability to localize sound and to understand speech in …

Contralateral interference caused by binaurally presented competing speech in adult bilateral cochlear-implant users

MJ Goupell, OA Stakhovskaya, JGW Bernstein - Ear and hearing, 2018 - journals.lww.com
Objectives: Bilateral cochlear implants (BI-CIs) are intended to improve sound localization
and speech understanding in the presence of interfering sounds. For normal-hearing …

Health State Utility Values Associated with Cochlear implants in adults: a systematic review and network Meta-analysis

PR Dixon, J Shapiro, G Tomlinson, J Cottrell… - Ear and …, 2023 - journals.lww.com
Objectives: The cost-effectiveness of bilateral cochlear implants in adults remains uncertain
despite established clinical benefits. In cost-effectiveness studies, benefit is often measured …