BACKGROUND Tumor-associated trypsin inhibitor (TATI) was originally isolated from the
urine of a patient with ovarian cancer. It was later shown to be produced by many other …

Purpose Multiple-gene sequencing is entering practice, but its clinical value is unknown. We
evaluated the performance of a customized germline-DNA sequencing panel for cancer-risk …

Tumor-associated trypsin inhibitor (TATI)[also called serine peptidase inhibitor Kazal type1,
SPINK1 and, in the pancreas, pancreatic secretory trypsin inhibitor (PSTI)] inhibits trypsin …

Jumonji domain-containing 6 (JMJD6) is a member of the Jumonji C domain-containing
family of proteins. Compared to other members of the family, the cellular activity of JMJD6 is …

Introduction We developed an analytic strategy that correlates gene expression and clinical
outcomes as a means to identify novel candidate oncogenes operative in breast cancer …

Abstract Purpose: Serine peptidase inhibitor, Kazal type-1 (SPINK1) overexpression defines
the second most recurrent and aggressive prostate cancer subtype. However, the underlying …

Multigene panel testing of breast cancer predisposition genes have been extensively
conducted in Europe and America, which is relatively rare in Asia however. In this study, we …

Hepatocellular carcinoma (HCC) undergoes a stepwise progression from liver cirrhosis to
low-grade dysplastic nodule (LGDN), high-grade dysplastic nodule (HGDN), early HCC …

Hypoxia is associated with tumor radioresistance; therefore, a predictive marker for tumor
hypoxia and a rational target to overcome it have been sought to realize personalized …

Triple-negative breast cancer (TNBC) has the worst prognosis of any breast cancer subtype.
To better understand the genetic forces driving TNBC, we performed a transposon …