The anti-viral facet of anti-rheumatic drugs: Lessons from COVID-19

C Perricone, P Triggianese, E Bartoloni, G Cafaro… - Journal of …, 2020 - Elsevier
The outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection has posed the world at a pandemic risk. Coronavirus-19 disease (COVID-19) is an …

Neurotropic enterovirus infections in the central nervous system

HI Huang, SR Shih - Viruses, 2015 - mdpi.com
Enteroviruses are a group of positive-sense single stranded viruses that belong to the
Picornaviridae family. Most enteroviruses infect humans from the gastrointestinal tract and …

Cleavage of the adaptor protein TRIF by enterovirus 71 3C inhibits antiviral responses mediated by Toll-like receptor 3

X Lei, Z Sun, X Liu, Q Jin, B He, J Wang - Journal of virology, 2011 - Am Soc Microbiol
ABSTRACT Enterovirus 71 (EV71) causes hand-foot-and-mouth disease and neurological
complications in young children. Although the underlying mechanisms remain obscure …

Cleavage of interferon regulatory factor 7 by enterovirus 71 3C suppresses cellular responses

X Lei, X Xiao, Q Xue, Q Jin, B He, J Wang - Journal of virology, 2013 - Am Soc Microbiol
ABSTRACT Enterovirus 71 (EV71) is a positive-stranded RNA virus which is capable of
inhibiting innate immunity. Among virus-encoded proteins, the 3C protein compromises the …

Targeting macrophages as a therapeutic option in coronavirus disease 2019

M Gracia-Hernandez, EM Sotomayor… - Frontiers in …, 2020 - frontiersin.org
Immune cells of the monocyte/macrophage lineage are characterized by their diversity,
plasticity, and variety of functions. Among them, macrophages play a central role in antiviral …

EV71 infection induces neurodegeneration via activating TLR7 signaling and IL-6 production

Z Luo, R Su, W Wang, Y Liang, X Zeng… - PLoS …, 2019 - journals.plos.org
As a neurotropic virus, human Enterovirus 71 (EV71) infection causes hand-foot-and-mouth
disease (HFMD) and may develop severe neurological disorders in infants. Toll-like receptor …

A non-mouse-adapted enterovirus 71 (EV71) strain exhibits neurotropism, causing neurological manifestations in a novel mouse model of EV71 infection

WX Khong, B Yan, H Yeo, EL Tan, JJ Lee… - Journal of …, 2012 - Am Soc Microbiol
ABSTRACT Enterovirus 71 (EV71) is a neurotropic pathogen that has been consistently
associated with the severe neurological forms of hand, foot, and mouth disease. The lack of …

Cytokine immunopathogenesis of enterovirus 71 brain stem encephalitis

SM Wang, HY Lei, CC Liu - Journal of Immunology Research, 2012 - Wiley Online Library
Enterovirus 71 (EV71) is one of the most important causes of herpangina and hand, foot,
and mouth disease. It can also cause severe complications of the central nervous system …

Virulent pseudorabies virus infection induces a specific and lethal systemic inflammatory response in mice

K Laval, JB Vernejoul, J Van Cleemput… - Journal of …, 2018 - Am Soc Microbiol
Pseudorabies virus (PRV) is an alphaherpesvirus that infects the peripheral nervous system
(PNS). The natural host of PRV is the swine, but it can infect most mammals, including cattle …

Thiamine and riboflavin inhibit production of cytokines and increase the anti-inflammatory activity of a corticosteroid in a chronic model of inflammation induced by …

RR Menezes, AM Godin, FF Rodrigues… - Pharmacological …, 2017 - Elsevier
Background The effects induced by thiamine and riboflavin, isolated or in association with
corticosteroids, in models of chronic inflammation are not known. Thus, we evaluated the …