Smokeless tobacco and cigarette smoking: chemical mechanisms and cancer prevention

SS Hecht, DK Hatsukami - Nature Reviews Cancer, 2022 - nature.com
Tobacco products present a deadly combination of nicotine addiction and carcinogen
exposure resulting in millions of cancer deaths per year worldwide. A plethora of smokeless …

The tobacco smoke component, acrolein, as a major culprit in lung diseases and respiratory cancers: Molecular mechanisms of acrolein cytotoxic activity

P Hikisz, D Jacenik - Cells, 2023 - mdpi.com
Acrolein, a highly reactive unsaturated aldehyde, is a ubiquitous environmental pollutant
that seriously threatens human health and life. Due to its high reactivity, cytotoxicity and …

Lung carcinogenesis by tobacco smoke

SS Hecht - International journal of cancer, 2012 - Wiley Online Library
Cigarette smoke is a complex mixture of chemicals including multiple genotoxic lung
carcinogens. The classic mechanisms of carcinogen metabolic activation to DNA adducts …

Origin and fate of acrolein in foods

K Jiang, C Huang, F Liu, J Zheng, J Ou, D Zhao, S Ou - Foods, 2022 - mdpi.com
Acrolein is a highly toxic agent that may promote the occurrence and development of various
diseases. Acrolein is pervasive in all kinds of foods, and dietary intake is one of the main …

Acrolein–a pulmonary hazard

K Bein, GD Leikauf - Molecular nutrition & food research, 2011 - Wiley Online Library
Acrolein is a respiratory irritant that can be generated during cooking and is in
environmental tobacco smoke. More plentiful in cigarette smoke than polycyclic aromatic …

Toxicology and risk assessment of acrolein in food

K Abraham, S Andres, R Palavinskas… - Molecular nutrition & …, 2011 - Wiley Online Library
Acrolein is an α, β‐unsaturated aldehyde formed by thermal treatment of animal and
vegetable fats, carbohydrates and amino acids. In addition it is generated endogenously. As …

DNA damage, DNA repair and carcinogenicity: Tobacco smoke versus electronic cigarette aerosol

M Tang, HW Lee, M Weng, HT Wang, Y Hu… - … Research/Reviews in …, 2022 - Elsevier
The allure of tobacco smoking is linked to the instant gratification provided by inhaled
nicotine. Unfortunately, tobacco curing and burning generates many mutagens including …

DNA and protein adducts in human tissues resulting from exposure to tobacco smoke

DH Phillips, S Venitt - International journal of cancer, 2012 - Wiley Online Library
Tobacco smoke contains a variety of genotoxic carcinogens that form adducts with DNA and
protein in the tissues of smokers. Not only are these biochemical events relevant to the …

Damage of DNA and proteins by major lipid peroxidation products in genome stability

A Winczura, D Zdżalik, B Tudek - Free Radical Research, 2012 - Taylor & Francis
Oxidative stress and lipid peroxidation (LPO) accompanying infections and chronic
inflammation may induce several human cancers. LPO products are characterized by …

Recent studies on DNA adducts resulting from human exposure to tobacco smoke

B Ma, I Stepanov, SS Hecht - Toxics, 2019 - mdpi.com
DNA adducts are believed to play a central role in the induction of cancer in cigarette
smokers and are proposed as being potential biomarkers of cancer risk. We have …