Pervasive roles of microRNAs in cardiovascular biology

EM Small, EN Olson - Nature, 2011 - nature.com
First recognized as regulators of development in worms and fruitflies, microRNAs are
emerging as pivotal modulators of mammalian cardiovascular development and disease …

Mechanisms of thrombosis in obesity

IO Blokhin, SR Lentz - Current opinion in hematology, 2013 - journals.lww.com
Obesity-driven chronic inflammation and impaired fibrinolysis appear to be major effector
mechanisms of thrombosis in obesity. The proinflammatory and hypofibrinolytic effects of …

Impact of periodontitis on gingival crevicular fluid miRNAs profiles associated with cardiovascular disease risk

G Isola, S Santonocito, A Distefano… - Journal of …, 2023 - Wiley Online Library
Abstract Background and Objective Recent emerging evidence has shown that microRNA
(miRNAs) is involved in several epigenetic processes linked with periodontitis, increased …

Diabetes mellitus-associated vascular impairment: novel circulating biomarkers and therapeutic approaches

D Tousoulis, N Papageorgiou, E Androulakis… - Journal of the American …, 2013 - jacc.org
It is widely accepted that diabetes mellitus (DM) impairs endothelial nitric oxide synthase
activity as well as enhances the production of reactive oxygen species, thus resulting in …

Mesenchymal stem cell therapy: A promising cell‐based therapy for treatment of myocardial infarction

AES Shafei, MA Ali, HG Ghanem… - The journal of gene …, 2017 - Wiley Online Library
For decades, mesenchymal stem (MSCs) cells have been used for cardiovascular diseases
as regenerative therapy. This review is an attempt to summarize the types of MSCs involved …

Postischemic revascularization: from cellular and molecular mechanisms to clinical applications

JS Silvestre, DM Smadja, BI Levy - Physiological reviews, 2013 - journals.physiology.org
After the onset of ischemia, cardiac or skeletal muscle undergoes a continuum of molecular,
cellular, and extracellular responses that determine the function and the remodeling of the …

[HTML][HTML] Redox-related biomarkers in human cardiovascular disease-classical footprints and beyond

A Daiber, O Hahad, I Andreadou, S Steven, S Daub… - Redox Biology, 2021 - Elsevier
Global epidemiological studies show that chronic non-communicable diseases such as
atherosclerosis and metabolic disorders represent the leading cause of premature mortality …

MicroRNA signatures in total peripheral blood as novel biomarkers for acute myocardial infarction

B Meder, A Keller, B Vogel, J Haas… - Basic research in …, 2011 - Springer
MicroRNAs (miRNAs) are important regulators of adaptive and maladaptive responses in
cardiovascular diseases and hence are considered to be potential therapeutical targets …

Downregulation of microRNA-126 in endothelial progenitor cells from diabetes patients, impairs their functional properties, via target gene Spred-1

S Meng, JT Cao, B Zhang, Q Zhou, CX Shen… - Journal of molecular and …, 2012 - Elsevier
Diabetes mellitus (DM) adversely affects the number and function of circulating endothelial
progenitor cells (EPCs). Consequently, there is also a reduction in the repair mechanism of …

MicroRNA-21: from cancer to cardiovascular disease

V Jazbutyte, T Thum - Current drug targets, 2010 - ingentaconnect.com
MicroRNA-21 (miR-21) expression is activated in multiple types of cancers, such as breast,
liver, brain, prostate, myometrial cancers but also in cardiovascular disease. MiR-21 …