The metabolism of the non-essential amino acid L-proline is emerging as a key pathway in
the metabolic rewiring that sustains cancer cells proliferation, survival and metastatic …

The expression of PARK7 is upregulated in various types of cancer, suggesting its potential
role as a critical regulator of the pathogenesis of cancer and in the treatment of cancer and …

Background Osteosarcoma is the most common type of primary malignant bone tumor. This
disease has exhibited a progressively lower survival rate over the past several decades …

Background Lung cancer remains the leading cause of cancer-related death worldwide. The
human PINK1 gene (PTEN induced kinase 1, Park6), an important gene for Parkinson's …

Several studies have reported the effects of DJ-1 gene and miR-199a/b-3p on HCC
development. However, whether miR-199a/b-3p regulates HCC progression through a …

Background & aims Transient regeneration–associated steatosis (TRAS) is a process of
temporary hepatic lipid accumulation and is essential for liver regeneration by providing …

Parkinson disease autosomal recessive, early onset 7 (PARK7 or DJ-1) is involved in
multiple physiological processes and exerts anti-apoptotic effects on multiple cell types …

The disease heterogeneity and little therapeutic progress in neurodegenerative diseases
justify the need for novel and effective drug discovery approaches. Drug repurposing is an …

Recently, circular RNAs (circRNAs) have attracted growing attention due to their pivotal
roles in the complicated cellular processes of diverse human malignancies, including …

The tumor suppressor phosphatase and tensin homologue (PTEN) is a redox-sensitive dual
specificity phosphatase with an essential role in the negative regulation of the PI3K-AKT …