Age-related macular degeneration (AMD) is the leading cause of severe irreversible central
vision loss in individuals over 65 years old. Genome-wide association studies (GWASs) …

Diabetic retinal disease (DRD), the most common complication of diabetes and a leading
cause of blindness in working age individuals, is now understood to be a form of sensory …

Age-related macular degeneration (AMD) is a leading cause of blindness, affecting 200
million people worldwide. To identify genes that could be targeted for treatment, we created …

Geographic atrophy (GA) secondary to age-related macular degeneration (AMD) is a retinal
neurodegenerative disorder. Human genetic data support the complement system as a key …

Age-related macular degeneration (AMD) is among the leading causes of irreversible
blindness worldwide. In addition to environmental risk factors, such as tobacco use and diet …

Age-related macular degeneration (AMD) and related macular dystrophies (MDs) primarily
affect the retinal pigment epithelium (RPE) in the eye. A hallmark of AMD/MDs that drives …

Age-related macular degeneration (AMD) is a major leading cause of irreversible visual
impairment in the world with limited therapeutic interventions. Histological, biochemical …

Genomic studies in age-related macular degeneration (AMD) have identified genetic
variants that account for the majority of AMD risk. An important next step is to understand the …

Dysregulation of the alternative pathway (AP) of the complement system is a significant
contributor to age-related macular degeneration (AMD), a primary cause of irreversible …

Background Single-variant associations with age-related macular degeneration (AMD), one
of the most prevalent causes of irreversible vision loss worldwide, have been studied …