Obesity is an important cause of morbidity and mortality in developed countries, and is also
becoming increasingly prevalent in the developing world. Although environmental factors …

The recognition that nutrients have the ability to interact and modulate molecular
mechanisms underlying an organism's physiological functions has prompted a revolution in …

BACKGROUND: Intra-peritoneal adipose tissue is recognized as a predictor of metabolic
syndrome and may contribute to the risk for cardiovascular disease by the production of …

摘要MicroRNAs (miRNAs) 对于包括真核生物基因表达在内的多个生物学过程都有着重要的内
源性调节作用. MiRNAs 相关的基因变化已被证实与人类疾病如2 型糖尿病相关. MiRNAs …

Recent evidence points to molecules secreted by the adipose tissue, or adipokines, as
possible links between increased adipose mass and metabolic abnormalities. Among these …

There is increasing evidence that dysregulation of energy homeostasis is associated with
colorectal carcinogenesis. Epidemiological data have consistently demonstrated a positive …

Body weight is a quantitative trait with significant heritability in humans. To identify potential
genetic contributors to this phenotype, we resequenced the coding exons and splice …

Background Adiponectin, secreted mainly by mature adipocytes, is a protein with insulin-
sensitising and anti-atherogenic effects. Human adiponectin is encoded by the ADIPOQ …

Type 2 diabetes mellitus is a complex metabolic disease that is caused by insulin resistance
and β-cell dysfunction. Furthermore, type 2 diabetes has an evident genetic component and …

The increasing prevalence of obesity and metabolic syndrome/insulin resistance has
attracted considerable interest due to their identification as risk factors for cardiovascular …