Human testis-expressed (TEX) genes: a review focused on spermatogenesis and male fertility

H Bellil, F Ghieh, E Hermel, B Mandon-Pepin… - Basic and clinical …, 2021 - Springer
Spermatogenesis is a complex process regulated by a multitude of genes. The identification
and characterization of male-germ-cell-specific genes is crucial to understanding the …

Redefining serological diagnostics with immunoaffinity proteomics

J Walter, Z Eludin, AP Drabovich - Clinical Proteomics, 2023 - Springer
Serological diagnostics is generally defined as the detection of specific human
immunoglobulins developed against viral, bacterial, or parasitic diseases. Serological tests …

APPRIS: selecting functionally important isoforms

JM Rodriguez, F Pozo, D Cerdán-Vélez… - Nucleic acids …, 2022 - academic.oup.com
Abstract APPRIS (https://appris. bioinfo. cnio. es) is a well-established database housing
annotations for protein isoforms for a range of species. APPRIS selects principal isoforms …

Evidence for widespread translation of 5′ untranslated regions

JM Rodriguez, F Abascal, D Cerdán-Vélez… - Nucleic Acids …, 2024 - academic.oup.com
Ribosome profiling experiments support the translation of a range of novel human open
reading frames. By contrast, most peptides from large-scale proteomics experiments derive …

Rational design and development of SARS-CoV-2 serological diagnostics by immunoprecipitation-targeted proteomics

Z Fu, Y Rais, D Dara, D Jackson… - Analytical …, 2022 - ACS Publications
Current design of serological tests utilizes conservative immunoassay approaches and is
focused on fast and convenient assay development, throughput, straightforward …

Obesity significantly alters the human sperm proteome, with potential implications for fertility

T Pini, J Parks, J Russ, M Dzieciatkowska… - Journal of Assisted …, 2020 - Springer
Purpose In men, obesity may lead to poor semen parameters and reduced fertility. However,
the causative links between obesity and male infertility are not totally clear, particularly on a …

Emerging role of novel seminal plasma bio-markers in Male infertility: a review

N Kumar, NK Singh - European Journal of Obstetrics & Gynecology and …, 2020 - Elsevier
Male infertility has emerged as an important cause of infertility worldwide. There are many
factors affecting male fertility and research is going on to know impact of various factors on …

Mapping isoform abundance and interactome of the endogenous TMPRSS2-ERG fusion protein by orthogonal immunoprecipitation–mass spectrometry assays

Z Fu, Y Rais, TA Bismar, ME Hyndman, XC Le… - Molecular & Cellular …, 2021 - ASBMB
TMPRSS2-ERG gene fusion, a molecular alteration found in nearly half of primary prostate
cancer cases, has been intensively characterized at the transcript level. However limited …

Mass spectrometry-based proteomics in basic and translational research of SARS-CoV-2 coronavirus and its emerging mutants

Y Rais, Z Fu, AP Drabovich - Clinical Proteomics, 2021 - Springer
Molecular diagnostics of the coronavirus disease of 2019 (COVID-19) now mainly relies on
the measurements of viral RNA by RT-PCR, or detection of anti-viral antibodies by …

Multi-omics biomarker pipeline reveals elevated levels of protein-glutamine gamma-glutamyltransferase 4 in seminal plasma of prostate cancer patients*[S]

AP Drabovich, P Saraon, M Drabovich… - Molecular & Cellular …, 2019 - ASBMB
Seminal plasma, because of its proximity to prostate, is a promising fluid for biomarker
discovery and noninvasive diagnostics. In this study, we investigated if seminal plasma …