Thiazole-based analogs as potential antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) and their SAR elucidation

J Guo, Z Xie, W Ruan, Q Tang, D Qiao, W Zhu - European Journal of …, 2023 - Elsevier
In recent years, the overuse of antibiotics has resulted in the emergence of antibiotic
resistance, which is a serious global health problem. Methicillin-resistant Staphylococcus …

Recent insights into antibacterial potential of benzothiazole derivatives

P Kashyap, S Verma, P Gupta, R Narang, S Lal… - Medicinal Chemistry …, 2023 - Springer
Antimicrobial resistance (AMR) is a worldwide concern among infectious diseases due to
increased mortality, morbidity and treatment cost. According to WHO 2019 report, among the …

In vitro and in vivo evaluation of the antimicrobial, antioxidant, cytotoxic, hemolytic activities and in silico POM/DFT/DNA-binding and pharmacokinetic analyses of …

SA Hassan, DM Aziz, MN Abdullah… - Journal of …, 2024 - Taylor & Francis
In this work, Schiff bases and Thiazolidin-4-ones, were synthesized using Sonication and
Microwave techniques, respectively. The Schiff base derivatives (3a–b) were synthesized …

Parsing structural fragments of thiazolidin-4-one based α-amylase inhibitors: A combined approach employing in vitro colorimetric screening and GA-MLR based …

R Singh, P Kumar, J Sindhu, M Devi, A Kumar… - Computers in Biology …, 2023 - Elsevier
Abstract α-Amylase (EC. 3.2. 1.1) is a ubiquitous digestive endoamylase. The abrupt rise in
blood glucose levels due to the hydrolysis of carbohydrates by α-amylase at a faster rate is …

Polypyridyl ruthenium complexes with benzothiazole moiety as membrane disruptors and anti-resistance agents for Staphylococcus aureus

W Deng, CY Zhang, LX Dou, LT Huang… - Journal of Inorganic …, 2024 - Elsevier
Developing new antimicrobials to combat drug-resistant bacterial infections is necessary
due to the increasing problem of bacterial resistance. In this study, four metallic ruthenium …

Thiazolidin-4-ones as a promising scaffold in the development of antibiofilm agents—A review

N Trotsko - International Journal of Molecular Sciences, 2023 - mdpi.com
Thiazolidin-4-ones have a broad range of medical and clinical implementation, which is
important for pharmaceutical and medicinal chemistry. This heterocyclic core has been …

Thiazolidinone‐Heterocycle Frameworks: A Concise Review of Their Pharmacological Significance

P Seboletswe, N Cele, P Singh - ChemMedChem, 2023 - Wiley Online Library
Molecular hybridization is deemed an optimistic approach in drug design and the discovery
of novel biologically active molecules as it may advance their affinity and potency while …

Discovery of benzothiazole-based thiazolidinones as potential anti-inflammatory agents: Anti-inflammatory activity, soybean lipoxygenase inhibition effect and …

M Haroun, A Petrou, C Tratrat, K Kositsi… - SAR and QSAR in …, 2022 - Taylor & Francis
Despite the greatest achievement in the development of anti-inflammatory agents in the last
two decades, the current clinical drugs suffer from a variety of complications in community …

Quantitative structure activity relationship (QSAR) modeling study of some novel thiazolidine 4-one derivatives as potent anti-tubercular agents

A Moulishankar… - Journal of Receptors and …, 2023 - Taylor & Francis
This study aims to develop a QSAR model for Antitubercular activity. The quantitative
structure-activity relationship (QSAR) approach predicted the thiazolidine-4-ones …

[HTML][HTML] Proton tautomerism and stereoisomerism in isomeric 4-(metoxyphenyl) amino-1, 3-thiazol-2 (5H)-one derivatives: Synthesis, crystal structure and …

A Pyrih, A Łapiński, S Zięba, A Mizera, R Lesyk… - Journal of Molecular …, 2024 - Elsevier
In this article, we have reported the most recent results of our systematic studies of phenyl-
ring substituent effect on proton tautomerism and stereoisomerism in 4-phenylamino-1, 3 …