Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

Neurofibrillary tangles, one of the neuropathologic hallmarks of Alzheimer's disease, have a
dynamic lifespan of maturity that associates with progressive neuronal dysfunction and …

Alzheimer's disease (AD) is an insidious and progressive neurodegenerative disorder that
affects millions of people worldwide. Although the pathogenesis remains obscure, there are …

Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

Formation of membrane-less organelles via liquid-liquid phase separation is one way cells
meet the biological requirement for spatiotemporal regulation of cellular components and …

In multiple neurodegenerative diseases, including Alzheimer's disease (AD), a prominent
pathological feature is the aberrant aggregation and inclusion formation of the microtubule …

Accumulation of misfolded and aggregated forms of tau protein in the brain is a
neuropathological hallmark of tauopathies, such as Alzheimer's disease and frontotemporal …

Alzheimer's disease (AD) is a neurodegenerative disease with complex pathological
characteristics, whose etiology and pathogenesis are still unclear. Over the past few …

With predictions showing that 131.5 million people worldwide will be living with dementia by
2050, an understanding of the molecular mechanisms underpinning disease is crucial in the …

Many neurodegenerative diseases are rooted in the activities of amyloid-like proteins which
possess conformations that spread to healthy proteins. These include Alzheimer's disease …