Nonconjugated hydrocarbons as rigid‐linear motifs: Isosteres for material sciences and bioorganic and medicinal chemistry

GM Locke, SSR Bernhard… - Chemistry–A European …, 2019 - Wiley Online Library
Abstract Nonconjugated hydrocarbons, like bicyclo [1.1. 1] pentane, bicyclo [2.2. 2] octane,
triptycene, and cubane are a unique class of rigid linkers. Due to their similarity in size and …

Geometry-controlled reactivity and dynamics in organic molecules

PK Saha, T Tran Ngoc, PR McGonigal, JF Teichert - Nature Synthesis, 2024 - nature.com
It is well established that strain in organic molecules is linked to having nonideal bond
lengths, bond angles and unfavourable non-covalent interactions. The constrained …

Controlling piezoresistance in single molecules through the isomerisation of bullvalenes

JR Reimers, T Li, AP Birvé, L Yang… - Nature …, 2023 - nature.com
Nanoscale electro-mechanical systems (NEMS) displaying piezoresistance offer unique
measurement opportunities at the sub-cellular level, in detectors and sensors, and in …

Shapeshifting bullvalene-linked vancomycin dimers as effective antibiotics against multidrug-resistant gram-positive bacteria

A Ottonello, JA Wyllie, O Yahiaoui… - Proceedings of the …, 2023 - National Acad Sciences
The alarming rise in superbugs that are resistant to drugs of last resort, including
vancomycin-resistant enterococci and staphylococci, has become a significant global health …

Molecular Ball Joints: Mechanochemical Perturbation of Bullvalene Hardy–Cope Rearrangements in Polymer Networks

PB Sun, MN Pomfret, MJ Elardo, A Suresh… - Journal of the …, 2024 - ACS Publications
The solution-state fluxional behavior of bullvalene has fascinated physical organic and
supramolecular chemists alike. Little effort, however, has been put into investigating …

Stochastic Bullvalene Architecture Modulates Structural Rigidity in π‐Rich Macromolecules

MN Pomfret, PB Sun, Z Huang… - Angewandte Chemie …, 2023 - Wiley Online Library
The synthesis and processing of π‐rich polymers found in novel electronics and textiles is
difficult because chain stiffness leads to low solubility and high thermal transitions. The …

Shapeshifting molecules: the story so far and the shape of things to come

AN Bismillah, BM Chapin, BA Hussein… - Chemical …, 2020 - pubs.rsc.org
Shapeshifting molecules exhibit rapid constitutional dynamics while remaining stable,
isolable molecules, making them promising artificial scaffolds from which to explore complex …

Guest‐Dependent Isomer Convergence of a Permanently Fluxional Coordination Cage

AP Birvé, HD Patel, JR Price, WM Bloch… - Angewandte …, 2022 - Wiley Online Library
A fluxional bis‐monodentate ligand, based on the archetypal shape‐shifting molecule
bullvalene, self‐assembles with M2+ (M= Pd2+ or Pt2+) to produce a highly complex …

Modular, Enantioselective Entry into Polysubstituted Shapeshifting Molecules

A Sanchez, VM Gonzalez, J Sakamoto… - Journal of the …, 2024 - ACS Publications
Dynamic, shapeshifting hydrocarbons have emerged as enabling frameworks across drug
discovery, materials science, and catalysis. Their employment, however, is often hampered …

Electromechanics of the Molecule–Electrode Interface and Interface-Mediated Effects in Single-Molecule Junctions

Y Zhu, Y Xu, Y Liu, H Liu, W Hong - ACS Applied Materials & …, 2025 - ACS Publications
The molecule–electrode interface can regulate both the efficiency and pathways of electron
transport through single-molecule junctions (SMJs). The electromechanics of the interface …