T Glomb, P Świątek - International journal of molecular sciences, 2021 - mdpi.com
The worldwide development of antimicrobial resistance forces scientists to search for new compounds to which microbes would be sensitive. Many new structures contain the 1, 3, 4 …
Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained considerable attention in the field of contemporary medicinal chemistry. The moiety is of …
A series of novel piperazine tethered biphenyl-3-oxo-1, 2, 4-triazine derivatives were designed, and synthesized. Amongst the synthesized analogs, compound 6g showed …
Innate inflammation beyond a threshold is a significant problem involved in cardiovascular diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
1, 3, 4-Oxadiazole, a five-membered aromatic ring can be seen in a number of synthetic molecules. The peculiar structural feature of 1, 3, 4-oxadiazole ring with pyridine type of …
MJ Akhtar, AA Siddiqui, AA Khan, Z Ali… - European Journal of …, 2017 - Elsevier
The synthesis of benzimidazole linked oxadiazole derivatives designed as potential EGFR and erbB2 receptor inhibitors with anticancer and apoptotic activity were studied …
M Patel, G Avashthi, A Gacem, MS Alqahtani, HK Park… - Molecules, 2023 - mdpi.com
Heterocyclic compounds are significant lead drug candidates based on their various structure–activity relationships (SAR), and their use in pharmaceutics is constantly …
A Ibrar, SA Shehzadi, F Saeed, I Khan - Bioorganic & Medicinal Chemistry, 2018 - Elsevier
Hybrid drugs featuring two or more potentially bioactive pharmacophores have been recognized as advanced and superior chemical entities to simultaneously modulate multiple …
Parkinson's disease (PD) is a progressive neurodegenerative disorder with a complex etiology. Neuroinflammation and oxidative stress are important factors driving the …