Recent advance in oxazole-based medicinal chemistry

HZ Zhang, ZL Zhao, CH Zhou - European journal of medicinal chemistry, 2018 - Elsevier
Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …

Antimicrobial activity of 1, 3, 4-oxadiazole derivatives

T Glomb, P Świątek - International journal of molecular sciences, 2021 - mdpi.com
The worldwide development of antimicrobial resistance forces scientists to search for new
compounds to which microbes would be sensitive. Many new structures contain the 1, 3, 4 …

Therapeutic evolution of benzimidazole derivatives in the last quinquennial period

W Akhtar, MF Khan, G Verma… - European journal of …, 2017 - Elsevier
Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …

Biphenyl-3-oxo-1, 2, 4-triazine linked piperazine derivatives as potential cholinesterase inhibitors with anti-oxidant property to improve the learning and memory

PN Tripathi, P Srivastava, P Sharma, MK Tripathi… - Bioorganic …, 2019 - Elsevier
A series of novel piperazine tethered biphenyl-3-oxo-1, 2, 4-triazine derivatives were
designed, and synthesized. Amongst the synthesized analogs, compound 6g showed …

Design and Development of COX-II Inhibitors: Current Scenario and Future Perspective

S Chahal, P Rani, Kiran, J Sindhu, G Joshi… - ACS …, 2023 - ACS Publications
Innate inflammation beyond a threshold is a significant problem involved in cardiovascular
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …

A review exploring therapeutic worth of 1, 3, 4-oxadiazole tailored compounds

G Verma, MF Khan, W Akhtar, MM Alam… - Mini Reviews in …, 2019 - ingentaconnect.com
1, 3, 4-Oxadiazole, a five-membered aromatic ring can be seen in a number of synthetic
molecules. The peculiar structural feature of 1, 3, 4-oxadiazole ring with pyridine type of …

Design, synthesis, docking and QSAR study of substituted benzimidazole linked oxadiazole as cytotoxic agents, EGFR and erbB2 receptor inhibitors

MJ Akhtar, AA Siddiqui, AA Khan, Z Ali… - European Journal of …, 2017 - Elsevier
The synthesis of benzimidazole linked oxadiazole derivatives designed as potential EGFR
and erbB2 receptor inhibitors with anticancer and apoptotic activity were studied …

A Review of Approaches to the Metallic and Non-Metallic Synthesis of Benzimidazole (BnZ) and Their Derivatives for Biological Efficacy

M Patel, G Avashthi, A Gacem, MS Alqahtani, HK Park… - Molecules, 2023 - mdpi.com
Heterocyclic compounds are significant lead drug candidates based on their various
structure–activity relationships (SAR), and their use in pharmaceutics is constantly …

Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery

A Ibrar, SA Shehzadi, F Saeed, I Khan - Bioorganic & Medicinal Chemistry, 2018 - Elsevier
Hybrid drugs featuring two or more potentially bioactive pharmacophores have been
recognized as advanced and superior chemical entities to simultaneously modulate multiple …

Novel flavonoid 1, 3, 4-oxadiazole derivatives ameliorate MPTP-induced Parkinson's disease via Nrf2/NF-κB signaling pathway

HW Meng, ZB Shen, XS Meng, ZQ Yin, XR Wang… - Bioorganic …, 2023 - Elsevier
Parkinson's disease (PD) is a progressive neurodegenerative disorder with a complex
etiology. Neuroinflammation and oxidative stress are important factors driving the …