The APOBEC (apolipoprotein B mRNA editing catalytic polypeptide-like) family of proteins
have diverse and important functions in human health and disease. These proteins have an …

Advances in next-generation sequencing and mass spectrometry have revealed widespread
messenger RNA modifications and RNA editing, with dramatic effects on mammalian …

The extent, regulation and enzymatic basis of RNA editing by cytidine deamination are
incompletely understood. Here we show that transcripts of hundreds of genes undergo site …

APOBEC3G is a cytidine deaminase with two homologous domains and restricts
retroelements and HIV-1. APOBEC3G deaminates single-stranded DNAs via its C-terminal …

APOBEC3 enzymes contribute significantly to DNA mutagenesis in cancer. These enzymes
are also capable of converting C bases at specific positions of RNAs to U. However, the …

RNA editing is a crucial post-transcriptional process that influences gene expression and
increases the diversity of the proteome as a result of amino acid substitution. Recently, the …

The 11-member APOBEC (apolipoprotein B mRNA editing catalytic polypeptide-like) family
of zinc-dependent cytidine deaminases bind to RNA and single-stranded DNA (ssDNA) and …

Rubella viruses (RV) have been found in an association with granulomas in children with
primary immune deficiencies (PID). Here, we report the recovery and characterization of …

One of the most prevalent epitranscriptomic modifications is RNA editing. In higher
eukaryotes, RNA editing is catalyzed by one of two classes of deaminases: ADAR family …

APOBEC3G, a member of the double-domain cytidine deaminase (CD) APOBEC, binds
RNA to package into virions and restrict HIV-1 through deamination-dependent or …