High copper promotes cell wall remodeling and oxidative stress in Histoplasma capsulatum, as revealed by proteomics

D Moraes, L do Prado Assunção, KLP da Silva… - Fungal Biology, 2023 - Elsevier
Histoplasma experiences nutritional stress during infection as a result of immune cells
manipulating essential nutrients, such as metal ions, carbon, nitrogen, and vitamins. Copper …

Insights into copper sensing and tolerance in Pneumocystis species

A Porollo, SG Sayson, A Ashbaugh, S Rebholz… - Frontiers in …, 2024 - frontiersin.org
Introduction Pneumocystis species are pathogenic fungi known to cause pneumonia in
immunocompromised mammals. They are obligate to their host, replicate extracellularly in …

A cysteine-rich domain of the Cuf1 transcription factor is required for high copper stress sensing and fungal virulence

C Probst, CA Denning-Jannace, M du Plooy… - bioRxiv, 2024 - biorxiv.org
The ability to sense, import but also detoxify copper (Cu) has been shown to be crucial for
microbial pathogens to survive within the host. Previous studies conducted with the …

Molecular aspects of copper homeostasis in fungi

D Moraes, MG Silva-Bailão… - Advances in applied …, 2024 - pubmed.ncbi.nlm.nih.gov
Copper homeostasis in fungi is a tightly regulated process crucial for cellular functions.
Fungi acquire copper from their environment, with transporters facilitating its uptake into the …