Emerging computational methods in mass spectrometry imaging

H Hu, J Laskin - Advanced Science, 2022 - Wiley Online Library
Mass spectrometry imaging (MSI) is a powerful analytical technique that generates maps of
hundreds of molecules in biological samples with high sensitivity and molecular specificity …

Mass spectrometry imaging of metals in tissues and cells: Methods and biological applications

BL Gorman, SV Torti, FM Torti, CR Anderton - Biochimica et Biophysica …, 2024 - Elsevier
Background Metals are pervasive throughout biological processes, where they play
essential structural and catalytic roles. Metals can also exhibit deleterious effects on human …

Multimodal high-resolution nano-DESI MSI and immunofluorescence imaging reveal molecular signatures of skeletal muscle fiber types

D Unsihuay, H Hu, J Qiu, A Latorre-Palomino… - Chemical …, 2023 - pubs.rsc.org
The skeletal muscle is a highly heterogeneous tissue comprised of different fiber types with
varying contractile and metabolic properties. The complexity in the analysis of skeletal …

[PDF][PDF] ICP-MS-based methodology in metallomics: towards single particle analysis, single cell analysis, and spatial metallomics

PP Chang, LN Zheng, B Wang, ML Chen, M Wang… - At …, 2022 - scholar.archive.org
As an emerging interdisciplinary science, metallomics aims to integrate research fields
related to metals and metalloids in biological systems from a systematic perspective …

Quantitative imaging approaches to understanding biological processing of metal ions

DZ Zee, KW MacRenaris, TV O'Halloran - Current opinion in chemical …, 2022 - Elsevier
Faster, more sensitive, and higher resolution quantitative instrumentation are aiding a
deeper understanding of how inorganic chemistry regulates key biological processes …

Elemental biomapping of human tissues suggests toxic metals such as mercury play a role in the pathogenesis of cancer

R Pamphlett, DP Bishop - Frontiers in Oncology, 2024 - pmc.ncbi.nlm.nih.gov
Toxic metals such as mercury, lead, and cadmium have multiple carcinogenic capacities,
including the ability to damage DNA and incite inflammation. Environmental toxic metals …

[HTML][HTML] Integrated elemental analysis supports targeting copper perturbations as a therapeutic strategy in multiple sclerosis

JBW Hilton, K Kysenius, JR Liddell, SW Mercer… - …, 2024 - Elsevier
Multiple sclerosis (MS) is a debilitating affliction of the central nervous system (CNS) that
involves demyelination of neuronal axons and neurodegeneration resulting in disability that …

Self-supervised clustering of mass spectrometry imaging data using contrastive learning

H Hu, JP Bindu, J Laskin - Chemical science, 2022 - pubs.rsc.org
Mass spectrometry imaging (MSI) is widely used for the label-free molecular mapping of
biological samples. The identification of co-localized molecules in MSI data is crucial to the …

[HTML][HTML] Artificial intelligence in surgical pathology–where do we stand, where do we go?

C Sagiv, O Hadar, A Najjar, J Pahnke - European Journal of Surgical …, 2024 - Elsevier
Surgical and neuropathologists continuously search for new and disease-specific features,
such as independent predictors of tumor prognosis or determinants of tumor entities and sub …

Atomic spectrometry update: review of advances in the analysis of clinical and biological materials, foods and beverages

M Patriarca, N Barlow, A Cross, S Hill… - Journal of Analytical …, 2023 - pubs.rsc.org
This update covers publications from the second half of 2021 to the middle of 2022.
Advances in the application of atomic spectrometry techniques to clinical and biological …