Midbrain dopaminergic (mDA) neuron development has been an intense area of research
during recent years. This is due in part to a growing interest in regenerative medicine and …

Dopaminergic (DA) neurons of the ventral midbrain (VM) play vital roles in the regulation of
voluntary movement, emotion and reward. They are divided into the A8, A9 and A10 …

Glial cell line–derived neurotrophic factor (GDNF) and its close relative neurturin are
currently in clinical trials for neuroprotection in patients with Parkinson disease (PD) …

Abstract Parkinson's disease (PD), the most common movement disorder, comprises several
pathophysiologic mechanisms including misfolded alpha‐synuclein aggregation …

The past two decades have seen an explosion in our understanding of the origin and
development of the midbrain dopamine system. Much of this work has been focused on the …

Neurogenic regions of mammalian brain produce many more neurons that will eventually
survive and reach a mature stage. Developmental cell death affects both embryonically …

Dopamine (DA) releasing midbrain neurons are essential for multiple brain functions, such
as voluntary movement, working memory, emotion and cognition. DA midbrain neurons …

The nervous system plays a central role in regulating the stem cell niche in many organs,
and thereby pivotally modulates development, homeostasis, and plasticity. A similarly …

Aims Glial cell‐derived neurotrophic factor (GDNF) is emerging as a potent neurotrophic
factor with therapeutic potential against a range of neurodegenerative conditions including …

Neurotrophins (NTs) are members of a neuronal growth factor protein family whose action is
mediated by the tropomyosin receptor kinase (TRK) receptor family receptors and the p75 …