Next-generation sequencing has revolutionized clinical diagnostic testing. Yet, for a
substantial proportion of patients, sequence information restricted to exons and exon–intron …

In many eukaryotes, including mammals, plants, yeast, and insects, introns can increase
gene expression without functioning as a binding site for transcription factors. This …

Mammalian genomes are pervasively transcribed, to produce thousands of long non-coding
RNAs (lncRNAs),. A few of these lncRNAs have been shown to recruit regulatory complexes …

We show that NF-κB and transcriptional targets are activated in liver by obesity and high-fat
diet (HFD). We have matched this state of chronic, subacute'inflammation'by low-level …

Precursor mRNA splicing is one of the most highly regulated processes in metazoan
species. In addition to generating vast repertoires of RNAs and proteins, splicing has a …

The pathway from gene activation in the nucleus to mRNA translation and decay at specific
locations in the cytoplasm is both streamlined and highly interconnected. This review …

Protein-coding genes in eukaryotes are transcribed by RNA polymerase II (Pol II) and
introns are removed from pre-mRNA by the spliceosome. Understanding the time lag …

MUTATIONS in the genes encoding amyloid-β precursor protein (APP) 1 presenilin 1 (PS1)
2 and presenilin 2 (PS2) 3, 4 are known to cause early-onset, autosomal dominant …

Pre-mRNA processing steps are tightly coordinated with transcription in many organisms. To
determine how co-transcriptional splicing is integrated with transcription elongation and 3 …

Although it has been known since the late 1970s that intron-containing and intronless
versions of otherwise identical genes can exhibit dramatically different expression profiles …