Exercise therapy for people with sarcopenic obesity: myokines and adipokines as effective actors

H Alizadeh Pahlavani - Frontiers in endocrinology, 2022 - frontiersin.org
Sarcopenic obesity is defined as a multifactorial disease in aging with decreased body
muscle, decreased muscle strength, decreased independence, increased fat mass, due to …

Skeletal muscle oxidative stress and inflammation in aging: Focus on antioxidant and anti-inflammatory therapy

M Chen, Y Wang, S Deng, Z Lian, K Yu - Frontiers in Cell and …, 2022 - frontiersin.org
With aging, the progressive loss of skeletal muscle will have negative effect on multiple
physiological parameters, such as exercise, respiration, thermoregulation, and metabolic …

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Q Zhong, X Xiao, Y Qiu, Z Xu, C Chen, B Chong… - MedComm, 2023 - Wiley Online Library
Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Fiber-type shifting in sarcopenia of old age: proteomic profiling of the contractile apparatus of skeletal muscles

P Dowling, S Gargan, D Swandulla… - International Journal of …, 2023 - mdpi.com
The progressive loss of skeletal muscle mass and concomitant reduction in contractile
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …

[HTML][HTML] Skeletal muscle mitochondrial remodeling in heart failure: An update on mechanisms and therapeutic opportunities

J Lv, Y Li, S Shi, X Xu, H Wu, B Zhang… - Biomedicine & …, 2022 - Elsevier
Patients with heart failure (HF) usually present with skeletal muscle diseases of varying
severity, ranging from early fatigue on exercise to sarcopenia, sarcopenic obesity or …

Organokines, sarcopenia, and metabolic repercussions: the vicious cycle and the interplay with exercise

G Minniti, LM Pescinini-Salzedas, GAS Minniti… - International journal of …, 2022 - mdpi.com
Sarcopenia is a disease that becomes more prevalent as the population ages, since it is
directly linked to the process of senility, which courses with muscle atrophy and loss of …

Role of hydroxytyrosol and oleuropein in the prevention of aging and related disorders: focus on neurodegeneration, skeletal muscle dysfunction and gut microbiota

L Micheli, L Bertini, A Bonato, N Villanova, C Caruso… - Nutrients, 2023 - mdpi.com
Aging is a multi-faceted process caused by the accumulation of cellular damage over time,
associated with a gradual reduction of physiological activities in cells and organs. This …

Lysyl oxidase‐like 2 inhibitor rescues D‐galactose‐induced skeletal muscle fibrosis

Y Wu, Y Wu, Y Yang, J Yu, J Wu, Z Liao, A Guo… - Aging …, 2022 - Wiley Online Library
Aging‐related sarcopenia is currently the most common sarcopenia. The main
manifestations are skeletal muscle atrophy, replacement of muscle fibers with fat and fibrous …

[HTML][HTML] The contribution of mitochondria to age-related skeletal muscle wasting: A sex-specific perspective

A Nuccio, R Nogueira-Ferreira, A Moreira-Pais… - Life Sciences, 2024 - Elsevier
As people age, their skeletal muscle (SkM) experiences a decline in mitochondrial
functionality and density, which leads to decreased energy production and increased …

7β-Hydroxycholesterol and 7-ketocholesterol: New oxidative stress biomarkers of sarcopenia inducing cytotoxic effects on myoblasts and myotubes

I Ghzaiel, A Zarrouk, V Pires, JPP de Barros… - The Journal of Steroid …, 2023 - Elsevier
Aging is a complex biological process which can be associated with skeletal muscle
degradation leading to sarcopenia. The aim of this study consisted i) to determine the …