Antimicrobial resistance to virtually all clinically applied antibiotic classes severely limits the
available options to treat bacterial infections. Hence, there is an urgent need to develop and …

Since the last revision of this article (2006), a number of important publications have
appeared in the literature, the inclusion of which made it necessary to limit the topics of this …

Genetic interactions identify functional connections between genes and pathways,
establishing gene functions or druggable targets. Here we use CRISPRi–TnSeq, CRISPRi …

Bacterial cell division and peptidoglycan (PG) synthesis are orchestrated by the coordinated
dynamic movement of essential protein complexes. Recent studies show that bidirectional …

Reproduction in the bacterial kingdom predominantly occurs through binary fission—a
process in which one parental cell is divided into two similarly sized daughter cells. How cell …

Most bacteria replicate and segregate their DNA concomitantly while growing, before cell
division takes place. How bacteria synchronize these different cell cycle events to ensure …

Prokaryotic cells display a striking subcellular organization. Studies of the underlying
mechanisms in different species have greatly enhanced our understanding of the …

Ovoid-shaped bacteria, such as Streptococcus pneumoniae (pneumococcus), have two
spatially separated peptidoglycan (PG) synthase nanomachines that locate zonally to the …

In bacteria, the dynamics of chromosome replication and segregation are tightly coordinated
with cell-cycle progression and largely rely on specific spatiotemporal arrangement of the …

Staphylococcus aureus is generally thought to divide in three alternating orthogonal planes
over three consecutive division cycles. Although this mode of division was proposed over …