Neurogenesis persists in adult mammals in specific brain areas, known as neurogenic
niches. Adult neurogenesis is highly dynamic and is modulated by multiple physiological …

Directed neuronal differentiation of human pluripotent stem cells (hPSCs), neural
progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly …

Type 2 diabetes affects over 300 million people, causing severe complications and
premature death, yet the underlying molecular mechanisms are largely unknown. Pancreatic …

The human cerebral cortex depends for its normal development and size on a precisely
controlled balance between self-renewal and differentiation of diverse neural progenitor …

The α and β cells act in concert to maintain blood glucose. The α cells release glucagon in
response to low levels of glucose to stimulate glycogenolysis in the liver. In contrast, β cells …

Sensory fibers of the peripheral nervous system carry sensation from specific sense
structures or use different tissues and organs as receptive fields, and convey this information …

Little is known of the intracellular machinery that controls the motility of newborn neurons.
We have previously shown that the proneural protein Neurog2 promotes the migration of …

Motility is a universal property of newly generated neurons. How cell migration is
coordinately regulated with other aspects of neuron production is not well understood. Here …

Cranial placodes (which include the adenohypophyseal, olfactory, lens, otic, lateral line,
profundal/trigeminal, and epibranchial placodes) give rise to many sense organs and …

Alpha and beta cells act in concert to maintain blood glucose. Alpha cells release glucagon
in response to low glucose to stimulate glycogenolysis in the liver. In contrast, beta cells …