Important flavonoids and their role as a therapeutic agent
Flavonoids are phytochemical compounds present in many plants, fruits, vegetables, and
leaves, with potential applications in medicinal chemistry. Flavonoids possess a number of …
leaves, with potential applications in medicinal chemistry. Flavonoids possess a number of …
Potential benefits of nobiletin, a citrus flavonoid, against Alzheimer's disease and Parkinson's disease
A Nakajima, Y Ohizumi - International journal of molecular sciences, 2019 - mdpi.com
Alzheimer's disease (AD), which is characterized by the presence of amyloid-β (Aβ) plaques
and neurofibrillary tangles, accompanied by neurodegeneration, is the most common form of …
and neurofibrillary tangles, accompanied by neurodegeneration, is the most common form of …
Neuroprotective effects of citrus fruit-derived flavonoids, nobiletin and tangeretin in Alzheimer's and Parkinson's disease
Neurodegenerative diseases, namely Alzheimer's disease and Parkinson's disease
represent a deleterious impact worldwide. Despite extensive preclinical and clinical …
represent a deleterious impact worldwide. Despite extensive preclinical and clinical …
The role of phytochemicals in the treatment and prevention of dementia
MJR Howes, E Perry - Drugs & aging, 2011 - Springer
Dementia pathologies such as Alzheimer's disease (AD) are reaching epidemic proportions,
yet they are not successfully managed by effective symptomatic treatments. Only five drugs …
yet they are not successfully managed by effective symptomatic treatments. Only five drugs …
Nobiletin, a citrus flavonoid, improves cognitive impairment and reduces soluble Aβ levels in a triple transgenic mouse model of Alzheimer's disease (3XTg-AD)
A Nakajima, Y Aoyama, EJ Shin, Y Nam, HC Kim… - Behavioural brain …, 2015 - Elsevier
Abstract Alzheimer's disease (AD), the most common form of dementia among the elderly, is
characterized by the progressive decline of cognitive function. Increasing evidence indicates …
characterized by the progressive decline of cognitive function. Increasing evidence indicates …
Anti-amnesic activity of Citrus aurantium flowers extract against scopolamine-induced memory impairments in rats
S Rahnama, Z Rabiei, Z Alibabaei, S Mokhtari… - Neurological …, 2015 - Springer
Alzheimer's disease (AD) is a progressive neurological disorder that mostly affects the
elderly population. Learning and memory impairment as the most characteristic …
elderly population. Learning and memory impairment as the most characteristic …
Nobiletin prevents amyloid β1-40-induced cognitive impairment via inhibition of neuroinflammation and oxidative/nitrosative stress
R Ghasemi-Tarie, Z Kiasalari, M Fakour… - Metabolic Brain …, 2022 - Springer
Alzheimer's disease (AD) is presented as an age-related neurodegenerative disease with
multiple cognitive deficits and amyloid β (Aβ) accumulation is the most important involved …
multiple cognitive deficits and amyloid β (Aβ) accumulation is the most important involved …
Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse
A Nakajima, Y Aoyama, TTL Nguyen, EJ Shin… - Behavioural Brain …, 2013 - Elsevier
Senescence-accelerated mouse prone 8 (SAMP8) is a model of aging characterized by the
early onset of learning and memory impairment and various pathological features of …
early onset of learning and memory impairment and various pathological features of …
Potent effects of flavonoid nobiletin on amplitude, period, and phase of the circadian clock rhythm in PER2:: LUCIFERASE mouse embryonic fibroblasts
A Shinozaki, K Misawa, Y Ikeda, A Haraguchi… - PloS one, 2017 - journals.plos.org
Flavonoids are natural polyphenols that are widely found in plants. The effects of flavonoids
on obesity and numerous diseases such as cancer, diabetes, and Alzheimer's have been …
on obesity and numerous diseases such as cancer, diabetes, and Alzheimer's have been …
Anti-neuroinflammatory activity of nobiletin on suppression of microglial activation
Y Cui, J Wu, SC Jung, DB Park, YH Maeng… - Biological and …, 2010 - jstage.jst.go.jp
A growing body of evidence suggests that nobiletin (5, 6, 7, 8, 3, 4-hexamethoxy flavone)
from the peel of citrus fruits, enhances the damaged cognitive function in disease animal …
from the peel of citrus fruits, enhances the damaged cognitive function in disease animal …