COVID-19-associated fungal infections

M Hoenigl, D Seidel, R Sprute, C Cunha… - Nature …, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19)-associated invasive fungal infections are an
important complication in a substantial number of critically ill, hospitalized patients with …

[HTML][HTML] ABC transporters affects tumor immune microenvironment to regulate cancer immunotherapy and multidrug resistance

J Fan, KKW To, ZS Chen, L Fu - Drug Resistance Updates, 2023 - Elsevier
Multidrug resistance (MDR) is the phenomenon in which cancer cells simultaneously
develop resistance to a broad spectrum of structurally and mechanistically unrelated drugs …

COVID-19 associated pulmonary aspergillosis (CAPA)—from immunology to treatment

A Arastehfar, A Carvalho, FL van de Veerdonk… - Journal of Fungi, 2020 - mdpi.com
Like severe influenza, coronavirus disease-19 (COVID-19) resulting in acute respiratory
distress syndrome (ARDS) has emerged as an important disease that predisposes patients …

Pathogenesis of respiratory viral and fungal coinfections

F Salazar, E Bignell, GD Brown, PC Cook… - Clinical Microbiology …, 2022 - Am Soc Microbiol
Individuals suffering from severe viral respiratory tract infections have recently emerged as
“at risk” groups for developing invasive fungal infections. Influenza virus is one of the most …

Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation

C Yao, T Veleva, L Scott Jr, S Cao, L Li, G Chen… - Circulation, 2018 - Am Heart Assoc
Background: Atrial fibrillation (AF) is frequently associated with enhanced inflammatory
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …

Inflammasomes and fibrosis

WJ Zhang, SJ Chen, SC Zhou, SZ Wu… - Frontiers in …, 2021 - frontiersin.org
Fibrosis is the final common pathway of inflammatory diseases in various organs. The
inflammasomes play an important role in the progression of fibrosis as innate immune …

Neutrophil extracellular traps (NETs) and damage‐associated molecular patterns (DAMPs): two potential targets for COVID‐19 treatment

S Cicco, G Cicco, V Racanelli… - Mediators of …, 2020 - Wiley Online Library
COVID‐19 is a pandemic disease caused by the new coronavirus SARS‐CoV‐2 that mostly
affects the respiratory system. The consequent inflammation is not able to clear viruses. The …

Aspergillus fumigatus morphology and dynamic host interactions

FL Van De Veerdonk, MS Gresnigt, L Romani… - Nature Reviews …, 2017 - nature.com
Aspergillus fumigatus is an environmental filamentous fungus that can cause life-threatening
disease in immunocompromised individuals. The interactions between A. fumigatus and the …

Autophagy and inflammation in chronic respiratory disease

AC Racanelli, SA Kikkers, AMK Choi, SM Cloonan - Autophagy, 2018 - Taylor & Francis
Persistent inflammation within the respiratory tract underlies the pathogenesis of numerous
chronic pulmonary diseases including chronic obstructive pulmonary disease, asthma and …

β-Glucan induces protective trained immunity against Mycobacterium tuberculosis infection: a key role for IL-1

SJ Moorlag, N Khan, B Novakovic, E Kaufmann… - Cell reports, 2020 - cell.com
Summary β-glucan is a potent inducer of epigenetic and functional reprogramming of innate
immune cells, a process called" trained immunity," resulting in an enhanced host response …