Nanomaterials offer unique physical, chemical and biological properties of interest for
medical imaging and therapy. Over the last two decades, there has been an increasing effort …

Recombinant viruses are the workhorse of modern neuroscience. Whether one would like to
understand a neuron's morphology, natural activity patterns, molecular composition …

Background Cerebral infarction ranks as the second leading cause of disability and death
globally, and inflammatory response of glial cells is the main cause of brain damage during …

While protein therapeutics are one of the most successful class of drug molecules, they are
expensive and not suited for treating chronic disorders that require long-term dosing. Adeno …

The development of transgenic mouse models that express genes of interest in specific cell
types has transformed our understanding of basic biology and disease. However …

Adeno-associated virus (AAV) has emerged as the most promising vector for in vivo human
gene therapy, with several therapeutic approvals in the last few years and countless more …

Rationale: Despite recent advances in the use of adeno-associated viruses (AAVs) as
potential vehicles for genetic intervention of central and peripheral nervous system …

A method is presented for quantitative analysis of the biodistribution of adeno-associated
virus (AAV) gene transfer vectors following in vivo administration. We used iodine-124 (I …

Based on studies in experimental animals demonstrating that administration of adeno-
associated virus (AAV) vectors to the cerebrospinal fluid (CSF) is an effective route to …

Small promoters capable of driving potent neuron-restricted gene expression are required to
support successful brain circuitry and clinical gene therapy studies. However, converting …