The essential goal of vaccination is to generate potent and long-term protection against
diseases. Among different vaccine modalities, prime-boost vaccine strategies could …

Cutaneous T cell lymphomas (CTCLs) are a heterogenous group of lymphoproliferative
disorders caused by clonally derived, skin-invasive T cells. Mycosis fungoides (MF) and …

Toll-like receptors (TLRs) are a family of pattern-recognition receptors that are an important
link between innate and adaptive immunity. Many established, as well as experimental …

A major challenge for immunologists has been the development of vaccines designed to
emphasize cellular immune responses. One particularly promising approach is the prime …

Induction and maintenance of antibody and T cell responses will be critical for developing a
successful vaccine against HIV. A rational approach for generating such responses is to …

CD8+ T cells play a central role in the resolution and containment of viral infections. A key
effector function of CD8+ T cells is their cytolytic activity toward infected cells. Here, we …

Nanoparticles are considered to be efficient tools for inducing potent immune responses by
an Ag carrier. In this study, we examined the effect of Ag-carrying biodegradable poly (γ …

One strategy to induce optimal cellular and humoral immune responses following
immunization is to use vaccines or adjuvants that target dendritic cells and B cells. Activation …

We previously showed that immunization with a combination of TLR and CD40 agonists
(combined TLR/CD40 agonist immunization) resulted in an expansion of Ag-specific CD8 T …

Vaccines are arguably the most powerful medical intervention in the fight against infectious
diseases. The enormity of the global human immunodeficiency virus type 1 (HIV)/acquired …