Mechanisms of epigenetic regulation, including DNA methylation, chromatin remodeling,
and histone post-translational modifications, are involved in multiple aspects of neuronal …

Huntington's disease is a late-onset neurodegenerative disease caused by a CAG
trinucleotide repeat in the gene encoding the huntingtin protein. Despite its well-defined …

Background: Long-non-coding RNAs (lncRNAs), RNA molecules longer than 200
nucleotides, have been involved in several biological processes and in a growing number of …

Brain microvascular endothelial cells (BMECs) are an essential component of the blood-
brain barrier (BBB) that shields the brain against toxins and immune cells. While BBB …

Gene therapy is rapidly emerging as a powerful therapeutic strategy for a wide range of
neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD) …

Age of Huntington's disease (HD) motoric onset is strongly related to the number of CAG
trinucleotide repeats in the huntingtin gene, suggesting that biological tissue age plays an …

Normal brain function depends on the interaction between highly specialized neurons that
operate within anatomically and functionally distinct brain regions. Neuronal specification is …

Epigenetic modifications such as histone methylation permit change in chromatin structure
without accompanying change in the underlying genomic sequence. A number of studies in …

Neural cultures derived from Huntington's disease (HD) patient-derived induced pluripotent
stem cells were used for'omics' analyses to identify mechanisms underlying …

The complexity of affected brain regions and cell types is a challenge for Huntington's
disease (HD) treatment. Here we use single nucleus RNA sequencing to investigate …