Akt/PKB is a serine/threonine protein kinase that functions as a critical regulator of cell
survival and proliferation. Akt/PKB family comprises three highly homologous members …

The endoplasmic reticulum (ER) is the largest single intracellular organelle, which is present
in all types of nerve cells. The ER is an interconnected, internally continuous system of …

The Akt family of serine/threonine protein kinases are key regulators of multiple aspects of
cell behaviour, including proliferation, survival, metabolism, and tumorigenesis. Growth …

cAMP can be either mitogenic or anti-mitogenic, depending on the cell type. We
demonstrated previously that cAMP inhibited the proliferation of normal renal epithelial cells …

Autosomal dominant polycystic kidney disease and autosomal recessive polycystic kidney
disease are the best known of a large family of inherited diseases characterized by the …

Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of many
diseases and in cancer therapy. Although the unfolded protein response is known to …

Background. Caloric restriction (CR) increases maximal life span in short-lived organisms,
and its effects are being explored in nonhuman primates. The objectives of this study were to …

Chloro-10-[3 (-dimethylamino) propyl] phenothiazine mono hydrochloride (chlorpromazine;
CPZ) is an antipsychotic agent that was originally developed to control psychotic disorders …

Objectives: Bolus infusion of lipid emulsion can reverse cardiac pharmacotoxicity caused by
local anesthetics and other lipophilic drugs. The mechanisms of this effect are not …

Chlormequat chloride (CCC), as a widely used plant growth regulator, can cause impaired
sperm quality and decreased testosterone synthesis in pubertal rats, but the underlying …