Reactive oxygen and nitrogen species (eg H 2 O 2, nitric oxide) confer redox regulation of
essential cellular signaling pathways such as cell differentiation, proliferation, migration and …

It has been shown that ROS (reactive oxygen species, superoxide and hydrogen peroxide)
regulate major epigenetic processes, DNA methylation and histone acetylation, although the …

The formation of reactive oxygen species (ROS) by the myeloid cell NADPH oxidase NOX2
is critical for the destruction of engulfed microorganisms. However, recent studies imply that …

In mammals, the NADPH oxidase family of enzymes comprises seven members: NOXs 1–5,
DUOX1, and DUOX2. All of these enzymes function to move an electron across cellular …

NADPH oxidase5 (Nox5) is a novel Nox isoform which has recently been recognized as
having important roles in the pathogenesis of coronary artery disease, acute myocardial …

Reactive oxygen species (ROS) form a class of molecules with both positive and negative
impacts on cellular health. Negatively, ROS may react with cellular constituents including …

Prostate cancer (PCa) is the most commonly diagnosed cancer and second leading cause
of male cancer death in Western nations. Thus, new treatment modalities are urgently …

Superoxide is a precursor of many free radicals and reactive oxygen species (ROS) in
biological systems. It has been shown that superoxide regulates major epigenetic processes …

Epidemiological studies have led scientists to postulate the developmental origins of health
and disease hypothesis for noncommunicable diseases such as diabetes, cardiovascular …

NADPH oxidase (Nox) variants Nox1, Nox2 and Nox4 are implicated in the progression of
liver fibrosis. However, the role of Nox5 is not yet known, mainly due to the lack of this …