Vitamin D is a pleiotropic secosteroid hormone important for health and disease prevention.
The actions of vitamin D are mediated by the vitamin D receptor that binds the active form of …

Vitamin D has pleiotropic effects that go beyond its traditional role in calcium homeostasis.
Hundreds of genes with vitamin D receptor response elements directly or indirectly influence …

Metabolic bone disease is a common complication of chronic kidney disease (CKD) and is
part of a broad spectrum of disorders of mineral metabolism that occur in this clinical setting …

Hyperparathyroidism occurs in most patients during the progression of chronic kidney
disease (CKD) and one of its initiating events, reduced serum levels of 1, 25 …

Adequate nutrition is essential for maintaining good oral health. Minerals such as
magnesium, calcium, and phosphorus found in the diet constitute the main structural …

In kidney disease, the progressive loss of renal capacity to produce calcitriol, the vitamin D
hormone, is a key contributor to elevations in parathyroid hormone (PTH) and mineral and …

The classic pathogenesis of secondary hyperparathyroidism (SHPT) began with the trade‐
off hypothesis based on parathyroid hormone hypersecretion brought about by renal failure …

Vitamin D is a steroid hormone crucial for bone mineral metabolism. In addition, vitamin D
has pleiotropic actions in the body, including anti-cancer actions. These anti-cancer …

Small decreases in serum Ca2+ and more prolonged increases in serum phosphate (Pi)
stimulate the parathyroid (PT) to secrete parathyroid hormone (PTH), and 1, 25 (OH) 2D3 …

The vitamin D endocrine system plays a central role in mineral ion homeostasis through the
actions of the vitamin D hormone, 1, 25-dihydroxyvitamin D3 [1, 25 (OH) 2D3], on the …