Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …

Bacterial sphingomyelinases and phospholipases are a heterogeneous group of esterases
which are usually surface associated or secreted by a wide variety of Gram-positive and …

Robust immune responses are essential for eliminating pathogens but must be metered to
avoid prolonged immune activation and potential host damage. Upon recognition of …

Adipose triglyceride lipase (ATGL) is the key-enzyme for the release of fatty acids (FAs) from
triacylglycerol (TG) stores during intracellular lipolysis producing FAs used for energy …

Legionella pneumophila grows intracellularly within the membrane-bound Legionella-
containing vacuole (LCV) established by proteins translocated via the bacterial type IV …

L egionella species are ubiquitous, waterborne bacteria that thrive in numerous ecological
niches. Yet, in contrast to many other environmental bacteria, L egionella spp. are also able …

A crucial step in the elimination of invading microbes by macrophages is phagosomal
maturation through heterotypic endosomal fusion. This process is controlled by the guanine …

Intravacuolar pathogens need to gradually expand their surrounding vacuole to
accommodate the growing number of bacterial offspring during intracellular replication. Here …

Rab proteins compose the largest family of small GTPases and control the different steps of
intracellular membrane traffic. More recently, they have been shown to also regulate cell …

Chlamydia is an obligate intracellular pathogen that develops in the host cell in a vacuole
termed the chlamydial inclusion. The prevailing concept of the chlamydial inclusion is of a …