The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …

Rho GTPases are molecular switches that regulate many essential cellular processes,
including actin dynamics, gene transcription, cell-cycle progression and cell adhesion …

Rho and rac, two members of the ras-related superfamily of small GTPases, regulate the
polymerization of actin to produce stress fibers and lamellipodia, respectively. We report …

Rho GTPases impact a number of activities important for oncogenesis. We describe a small
molecule inhibitor that blocks oncogenic transformation induced by various Rho GTPases in …

Rho GTPases control many aspects of cell behavior through the regulation of multiple signal
transduction pathways (Van Aelst and D'Souza-Schorey 1997; Hall 1998). Rho, Rac, and …

Wnt signaling via the Frizzled (Fz) receptor controls cell polarity and movement during
development, but the molecular nature of Wnt/Fz polarity signal transduction remains poorly …

Rho small GTPase regulates cell morphology, adhesion and cytokinesis through the actin
cytoskeleton. We have identified a protein, p140mDia, as a downstream effector of Rho. It is …

Summary c-Jun amino-terminal kinases (JNKs) and mitogen-activatedprotein kinases
(MAPKs) are closely related; however, they are independently regulated by a variety of …

Cellular asymmetry is critical for the development of multicellular organisms. Here we show
that homologues of proteins necessary for asymmetric cell division in Caenorhabditis …

The PAK family of kinases are regulated through interaction with the small GTPases Cdc42
and Rac1, but little is known of the signaling components immediately upstream or …