Challenges of fluoride pollution in environment: mechanisms and pathological significance of toxicity–a review

S Wu, Y Wang, M Iqbal, K Mehmood, Y Li, Z Tang… - Environmental …, 2022 - Elsevier
Fluoride is an important trace element in the living body. A suitable amount of fluoride has a
beneficial effect on the body, but disproportionate fluoride entering the body will affect …

Autophagy in bone remodeling: a regulator of oxidative stress

C Zhu, S Shen, S Zhang, M Huang, L Zhang… - Frontiers in …, 2022 - frontiersin.org
Bone homeostasis involves bone formation and bone resorption, which are processes that
maintain skeletal health. Oxidative stress is an independent risk factor, causing the …

Chemopreventive effects of hesperidin against paclitaxel-induced hepatotoxicity and nephrotoxicity via amendment of Nrf2/HO-1 and caspase-3/Bax/Bcl-2 signaling …

C Gur, FM Kandemir, C Caglayan, E Satıcı - Chemico-biological …, 2022 - Elsevier
Paclitaxel (PTX) is a widely used chemotherapeutic drug particularly effective against lung,
breast, and ovarian cancer, though its usefulness is limited due to its multi-organ toxicity …

Formation and repair of oxidatively generated damage in cellular DNA

J Cadet, KJA Davies, MHG Medeiros… - Free Radical Biology …, 2017 - Elsevier
In this review article, emphasis is placed on the critical survey of available data concerning
modified nucleobase and 2-deoxyribose products that have been identified in cellular DNA …

Histone modifications in epigenetic regulation of cancer: Perspectives and achieved progress

ME Neganova, SG Klochkov, YR Aleksandrova… - Seminars in Cancer …, 2022 - Elsevier
Epigenetic changes associated with histone modifications play an important role in the
emergence and maintenance of the phenotype of various cancer types. In contrast to direct …

Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK/PGC-1α/Sirt3

D Wang, L Cao, X Zhou, G Wang, Y Ma, X Hao… - Journal of hazardous …, 2022 - Elsevier
Oxidative stress and mitochondrial dysfunction contribute greatly to fluoride-induced
cognitive impairment and behavioural disorders. Honokiol, a natural biphenolic compound …

The pathogenesis of endemic fluorosis: Research progress in the last 5 years

W Wei, S Pang, D Sun - Journal of cellular and molecular …, 2019 - Wiley Online Library
Fluorine is one of the trace elements necessary for health. It has many physiological
functions, and participates in normal metabolism. However, fluorine has paradoxical effects …

Insights and implications of sexual dimorphism in osteoporosis

YY Zhang, N Xie, XD Sun, EC Nice, YC Liou, C Huang… - Bone research, 2024 - nature.com
Osteoporosis, a metabolic bone disease characterized by low bone mineral density and
deterioration of bone microarchitecture, has led to a high risk of fatal osteoporotic fractures …

Rutin protects rat liver and kidney from sodium valproate-induce damage by attenuating oxidative stress, ER stress, inflammation, apoptosis and autophagy

FM Kandemir, M Ileriturk, C Gur - Molecular biology reports, 2022 - Springer
Background The present study investigated the effects of rutin (RUT), which has various
biological and pharmacological properties, on liver and kidney damage caused by histone …

Biological activities and potential oral applications of N‐acetylcysteine: progress and prospects

Y Pei, H Liu, Y Yang, Y Yang, Y Jiao… - Oxidative medicine …, 2018 - Wiley Online Library
N‐Acetylcysteine (NAC), a cysteine prodrug and glutathione (GSH) precursor, has been
used for several decades in clinical therapeutic practices as a mucolytic agent and for the …