The neurobiology of depression and antidepressant action

P Willner, J Scheel-Krüger, C Belzung - Neuroscience & biobehavioral …, 2013 - Elsevier
We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

Altered γ-aminobutyric acid neurotransmission in major depressive disorder: a critical review of the supporting evidence and the influence of serotonergic …

AL Pehrson, C Sanchez - Drug design, development and therapy, 2015 - Taylor & Francis
Evidence suggesting that central nervous system γ-aminobutyric acid (GABA)
concentrations are reduced in patients with major depressive disorder (MDD) has been …

Altered expression of δGABAA receptors in health and disease

PD Whissell, I Lecker, DS Wang, J Yu, BA Orser - Neuropharmacology, 2015 - Elsevier
Abstract γ-Aminobutyric acid type A receptors that contain the δ subunit (δGABA A receptors)
are expressed in multiple types of neurons throughout the central nervous system, where …

Neuroscience-driven discovery and development of sleep therapeutics

M Dresler, VI Spoormaker, P Beitinger, M Czisch… - Pharmacology & …, 2014 - Elsevier
Until recently, neuroscience has given sleep research and discovery of better treatments of
sleep disturbances little attention, despite the fact that disturbed sleep has overwhelming …

In vivo electrophysiological recordings of the effects of antidepressant drugs

PJ Fitzgerald, BO Watson - Experimental Brain Research, 2019 - Springer
Antidepressant drugs are a standard biological treatment for various neuropsychiatric
disorders, yet relatively little is known about their electrophysiologic and synaptic effects on …

Leading compounds for the validation of animal models of psychopathology

V Micale, J Kucerova, A Sulcova - Cell and Tissue Research, 2013 - Springer
Modelling of complex psychiatric disorders, eg, depression and schizophrenia, in animals is
a major challenge, since they are characterized by certain disturbances in functions that are …

Acutely increasing δGABAA receptor activity impairs memory and inhibits synaptic plasticity in the hippocampus

PD Whissell, D Eng, I Lecker, LJ Martin… - Frontiers in neural …, 2013 - frontiersin.org
Extrasynaptic γ-aminobutyric acid type A (GABAA) receptors that contain the δ subunit
(δGABAA receptors) are expressed in several brain regions including the dentate gyrus …

The effect of Schisandra chinensis extracts on depression by noradrenergic, dopaminergic, GABAergic and glutamatergic systems in the forced swim test in mice

T Yan, M Xu, B Wu, Z Liao, Z Liu, X Zhao, K Bi, Y Jia - Food & function, 2016 - pubs.rsc.org
Schisandra chinensis (Turcz.) Baill., as a Chinese functional food, has been widely used in
neurological disorders including insomnia and Alzheimer's disease. The treatment of …

Neuronal stem cell and drug interactions: a systematic review and meta-analysis: concise review

M Ikhsan, A Palumbo, D Rose, M Zille… - Stem cells translational …, 2019 - academic.oup.com
Stem cell therapy is a promising treatment option for neurodegenerative diseases that
mostly affect geriatric patients who often suffer from comorbidities requiring multiple …

Excitatory/inhibitory equilibrium of the central amygdala nucleus gates anti-depressive and anxiolytic states in the hamster

R Alò, E Avolio, M Mele, F Storino, A Canonaco… - Pharmacology …, 2014 - Elsevier
Several studies have pointed to the amygdala as a main limbic station capable of regulating
different stressful states such as anxiety and depression. In this work it was our intention to …