Natively unfolded proteins

AL Fink - Current opinion in structural biology, 2005 - Elsevier
It is now clear that a significant fraction of eukaryotic genomes encode proteins with
substantial regions of disordered structure. In spite of the lack of structure, these proteins …

Protein export via the type III secretion system of the bacterial flagellum

M Halte, M Erhardt - Biomolecules, 2021 - mdpi.com
The bacterial flagellum and the related virulence-associated injectisome system of
pathogenic bacteria utilize a type III secretion system (T3SS) to export substrate proteins …

Bacterial flagella grow through an injection-diffusion mechanism

TT Renault, AO Abraham, T Bergmiller, G Paradis… - Elife, 2017 - elifesciences.org
The bacterial flagellum is a self-assembling nanomachine. The external flagellar filament,
several times longer than a bacterial cell body, is made of a few tens of thousands subunits …

Interactions of bacterial flagellar chaperone–substrate complexes with FlhA contribute to co‐ordinating assembly of the flagellar filament

M Kinoshita, N Hara, K Imada, K Namba… - Molecular …, 2013 - Wiley Online Library
Assembly of the bacterial flagellar filament is strictly sequential; the junction proteins, FlgK
and FlgL, are assembled at the distal end of the hook prior to the FliD cap, which supports …

Insight into structural remodeling of the FlhA ring responsible for bacterial flagellar type III protein export

N Terahara, Y Inoue, N Kodera, YV Morimoto… - Science …, 2018 - science.org
The bacterial flagellum is a supramolecular motility machine. Flagellar assembly begins with
the basal body, followed by the hook and finally the filament. A carboxyl-terminal …

Structural insights into the substrate specificity switch mechanism of the type III protein export apparatus

Y Inoue, Y Ogawa, M Kinoshita, N Terahara… - Structure, 2019 - cell.com
Bacteria use a type III protein export apparatus for construction of the flagellum, which
consists of the basal body, the hook, and the filament. FlhA forms a homo-nonamer through …

Interaction of a bacterial flagellar chaperone FlgN with FlhA is required for efficient export of its cognate substrates

T Minamino, M Kinoshita, N Hara… - Molecular …, 2012 - Wiley Online Library
FlgN chaperone acts as a bodyguard to protect its cognate substrates, FlgK and FlgL, from
proteolysis in the cytoplasm. Docking of the FlgN–FlgK complex with the FliI ATPase of the …

Immunoinformatics design of a novel multi-epitope peptide vaccine to combat multi-drug resistant infections caused by Vibrio vulnificus

G Abbas, I Zafar, S Ahmad, SS Azam - European Journal of Pharmaceutical …, 2020 - Elsevier
Multi-drug resistant Vibrio vulnificus is a Gram-negative bacillus responsible for diseases,
such as: sepsis, septicemia, gastroenteritis, and fatal necrotizing fasciitis in humans. The …

Bacterial flagellar axial structure and its construction

K Imada - Biophysical reviews, 2018 - Springer
The bacterial flagellum is a motile organelle composed of thousands of protein subunits. The
filamentous part that extends from the cell membrane is called the axial structure and …

Mucosal immunization with purified flagellin from Salmonella induces systemic and mucosal immune responses in C3H/HeJ mice

L Strindelius, M Filler, I Sjöholm - Vaccine, 2004 - Elsevier
This study investigated the immune response elicited in C3H/HeJ mice after oral, parenteral
and nasal immunization with purified flagellin from Salmonella enterica serovar Enteritidis …