Caspase-3 is a widely expressed member of a conserved family of proteins, generally
recognized for their activated proteolytic roles in the execution of apoptosis in cells …

Alzheimer disease (AD) is a major cause of age-related dementia. We do not fully
understand AD aetiology and pathogenesis, but oxidative damage is a key component. The …

Amyloid beta peptide (Aβ) is produced through the proteolytic processing of a
transmembrane protein, amyloid precursor protein (APP), by β-and γ-secretases. Aβ …

Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

Amyloid precursor protein (APP) is an evolutionarily conserved transmembrane protein and
a well-characterized precursor protein of amyloid-beta (Aβ) peptides, which accumulate in …

This report describes a novel, comprehensive, and personalized therapeutic program that is
based on the underlying pathogenesis of Alzheimer's disease, and which involves multiple …

Slowly but surely, Alzheimer's disease (AD) patients lose their memory and their cognitive
abilities, and even their personalities may change dramatically. These changes are due to …

Neuronal death underlies the symptoms of many human neurological disorders, including
Alzheimer's, Parkinson's and Huntington's diseases, stroke, and amyotrophic lateral …

The amyloid precursor protein (APP) has occupied a central position in Alzheimer's disease
(AD) pathophysiology, in large part due to the seminal role of amyloid-β peptide (Aβ), a …

Vaccinations with amyloid-β peptide (AB) can dramatically reduce amyloid deposition in a
transgenic mouse model of Alzheimer's disease. To determine if the vaccinations had …