Sequencing pools of individuals—mining genome-wide polymorphism data without big funding

C Schlötterer, R Tobler, R Kofler, V Nolte - Nature Reviews Genetics, 2014 - nature.com
The analysis of polymorphism data is becoming increasingly important as a complementary
tool to classical genetic analyses. Nevertheless, despite plunging sequencing costs …

Life-History Evolution and the Genetics of Fitness Components in Drosophila melanogaster

T Flatt - Genetics, 2020 - academic.oup.com
Life-history traits or “fitness components”—such as age and size at maturity, fecundity and
fertility, age-specific rates of survival, and life span—are the major phenotypic determinants …

Evolutionary genomics can improve prediction of species' responses to climate change

AM Waldvogel, B Feldmeyer, G Rolshausen… - Evolution …, 2020 - academic.oup.com
Global climate change (GCC) increasingly threatens biodiversity through the loss of species,
and the transformation of entire ecosystems. Many species are challenged by the pace of …

Genetic redundancy fuels polygenic adaptation in Drosophila

N Barghi, R Tobler, V Nolte, AM Jakšić, F Mallard… - PLoS …, 2019 - journals.plos.org
The genetic architecture of adaptive traits is of key importance to predict evolutionary
responses. Most adaptive traits are polygenic—ie, result from selection on a large number of …

Genomic evidence of rapid and stable adaptive oscillations over seasonal time scales in Drosophila

AO Bergland, EL Behrman, KR O'Brien… - PLoS …, 2014 - journals.plos.org
In many species, genomic data have revealed pervasive adaptive evolution indicated by the
fixation of beneficial alleles. However, when selection pressures are highly variable along a …

Combining experimental evolution with next-generation sequencing: a powerful tool to study adaptation from standing genetic variation

C Schlötterer, R Kofler, E Versace, R Tobler… - Heredity, 2015 - nature.com
Evolve and resequence (E&R) is a new approach to investigate the genomic responses to
selection during experimental evolution. By using whole genome sequencing of pools of …

Microbiome composition shapes rapid genomic adaptation of Drosophila melanogaster

SM Rudman, S Greenblum… - Proceedings of the …, 2019 - National Acad Sciences
Population genomic data has revealed patterns of genetic variation associated with
adaptation in many taxa. Yet understanding the adaptive process that drives such patterns is …

Genomic Evidence for Adaptive Inversion Clines in Drosophila melanogaster

M Kapun, DK Fabian, J Goudet… - Molecular biology and …, 2016 - academic.oup.com
Clines in chromosomal inversion polymorphisms—presumably driven by climatic gradients—
are common but there is surprisingly little evidence for selection acting on them. Here we …

Revisiting classic clines in Drosophila melanogaster in the age of genomics

JR Adrion, MW Hahn, BS Cooper - Trends in Genetics, 2015 - cell.com
Adaptation to spatially varying environments has been studied for decades, but advances in
sequencing technology are now enabling researchers to investigate the landscape of …

Genomic Analysis of European Drosophila melanogaster Populations Reveals Longitudinal Structure, Continent-Wide Selection, and Previously Unknown DNA …

M Kapun, MG Barrón, F Staubach… - Molecular Biology …, 2020 - academic.oup.com
Genetic variation is the fuel of evolution, with standing genetic variation especially important
for short-term evolution and local adaptation. To date, studies of spatiotemporal patterns of …