Two of the most prevalent human viruses worldwide, herpes simplex virus type 1 and type 2
(HSV-1 and HSV-2, respectively), cause a variety of diseases, including cold sores, genital …

In the decade since the discovery of the innate immune cyclic GMP–AMP synthase (cGAS)–
2′ 3′-cyclic GMP–AMP (cGAMP)–stimulator of interferon genes (STING) pathway, its …

Inflammasome biology is one of the most exciting and rapidly growing areas in immunology.
Over the past 10 years, inflammasomes have been recognized for their roles in the host …

Herpes simplex virus-1 (HSV-1) establishes latency preferentially in sensory neurons of
peripheral ganglia. A variety of stresses can induce recurrent reactivations of the virus …

Teleost fish possess an adaptive immune system associated with each of their mucosal
body surfaces. Evidence obtained from mucosal vaccination and mucosal infection studies …

SUMMARY Herpes simplex virus 1 (HSV-1) is very successful in establishing acute and
latent infections in humans by counteracting host antiviral innate immune responses. HSV-1 …

Many human cells can sense the presence of exogenous DNA during infection though the
cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second …

Although it has been appreciated for some years that cytosolic DNA is immune stimulatory, it
is only in the past five years that the molecular basis of DNA sensing by the innate immune …

The first line of host defense against infectious agents involves activation of innate immune
signaling pathways that recognize specific pathogen-associated molecular patterns …

Innate immune activation by macrophages is an essential part of host defence against
infection. Cytosolic recognition of microbial DNA in macrophages leads to induction of …