Regulation of AMPA receptor trafficking and synaptic plasticity
V Anggono, RL Huganir - Current opinion in neurobiology, 2012 - Elsevier
AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in
the brain. Dynamic changes in neuronal synaptic efficacy, termed synaptic plasticity, are …
the brain. Dynamic changes in neuronal synaptic efficacy, termed synaptic plasticity, are …
Membrane curvature and its generation by BAR proteins
Membranes are flexible barriers that surround the cell and its compartments. To execute vital
functions such as locomotion or receptor turnover, cells need to control the shapes of their …
functions such as locomotion or receptor turnover, cells need to control the shapes of their …
[HTML][HTML] Molecular mechanisms of SERT in platelets: regulation of plasma serotonin levels
CP Mercado, F Kilic - Molecular interventions, 2010 - ncbi.nlm.nih.gov
The serotonin transporter (SERT) on platelets is a primary mechanism for serotonin (5HT)
uptake from the blood plasma. Alteration in plasma 5HT level is associated with a number of …
uptake from the blood plasma. Alteration in plasma 5HT level is associated with a number of …
BAR domain proteins—a linkage between cellular membranes, signaling pathways, and the actin cytoskeleton
PJ Carman, R Dominguez - Biophysical reviews, 2018 - Springer
Actin filament assembly typically occurs in association with cellular membranes. A large
number of proteins sit at the interface between actin networks and membranes, playing …
number of proteins sit at the interface between actin networks and membranes, playing …
AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking
D Bissen, F Foss, A Acker-Palmer - Cellular and Molecular Life Sciences, 2019 - Springer
To correctly transfer information, neuronal networks need to continuously adjust their
synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of …
synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of …
Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD
Proteins containing PSD-95/Discs-large/ZO-1 homology (PDZ) domains play key roles in the
assembly and regulation of cellular signaling pathways and represent putative targets for …
assembly and regulation of cellular signaling pathways and represent putative targets for …
High‐energy water sites determine peptide binding affinity and specificity of PDZ domains
PDZ domains have well known binding preferences for distinct C‐terminal peptide motifs.
For most PDZ domains, these motifs are of the form [S/T]‐W‐[I/L/V]. Although the preference …
For most PDZ domains, these motifs are of the form [S/T]‐W‐[I/L/V]. Although the preference …
Deciphering the BAR code of membrane modulators
U Salzer, J Kostan, K Djinović-Carugo - Cellular and Molecular Life …, 2017 - Springer
The BAR domain is the eponymous domain of the “BAR-domain protein superfamily”, a
large and diverse set of mostly multi-domain proteins that play eminent roles at the …
large and diverse set of mostly multi-domain proteins that play eminent roles at the …
PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance
Secretory vesicles in endocrine cells store hormones such as growth hormone (GH) and
insulin before their release into the bloodstream. The molecular mechanisms governing …
insulin before their release into the bloodstream. The molecular mechanisms governing …
PICK1 mediates transient synaptic expression of GluA2-lacking AMPA receptors during glycine-induced AMPA receptor trafficking
N Jaafari, JM Henley, JG Hanley - Journal of Neuroscience, 2012 - Soc Neuroscience
The number and subunit composition of postsynaptic AMPA receptors (AMPARs) is a key
determinant of synaptic transmission. The vast majority of AMPARs contain GluA2 subunit …
determinant of synaptic transmission. The vast majority of AMPARs contain GluA2 subunit …