Small molecule metabolites: discovery of biomarkers and therapeutic targets

S Qiu, Y Cai, H Yao, C Lin, Y Xie, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Diabetic retinopathy: Involved cells, biomarkers, and treatments

J Ren, S Zhang, Y Pan, M Jin, J Li, Y Luo… - Frontiers in …, 2022 - frontiersin.org
Diabetic retinopathy (DR), a leading cause of vision loss and blindness worldwide, is
caused by retinal neurovascular unit dysfunction, and its cellular pathology involves at least …

Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells

Y Tian, F Zhang, Y Qiu, S Wang, F Li, J Zhao… - Nature biomedical …, 2021 - nature.com
Choroidal neovascularization induced by age-related macular degeneration and retinal
neovascularization induced by diabetic retinopathy—two leading causes of blindness—are …

Metabolomics in diabetic retinopathy: from potential biomarkers to molecular basis of oxidative stress

Q Jian, Y Wu, F Zhang - Cells, 2022 - mdpi.com
Diabetic retinopathy (DR), the leading cause of blindness in working-age adults, is one of
the most common complications of diabetes mellitus (DM) featured by metabolic disorders …

Design of Multi‐Shelled Hollow Cr2O3 Spheres for Metabolic Fingerprinting

R Li, Y Zhou, C Liu, C Pei, W Shu… - Angewandte Chemie …, 2021 - Wiley Online Library
Schizophrenia (SZ) detection enables effective treatment to improve the clinical outcome,
but objective and reliable SZ diagnostics are still limited. An ideal diagnosis of SZ suited for …

Metabolites as risk factors for diabetic retinopathy in patients with type 2 diabetes: a 12-year follow-up study

L Fernandes Silva, J Hokkanen… - The Journal of …, 2024 - academic.oup.com
Context Diabetic retinopathy (DR) is a specific microvascular complication in patients with
diabetes and the leading cause of blindness. Recent advances in omics, especially …

Proteolytic rewiring of mitochondria by LONP1 directs cell identity switching of adipocytes

T Fu, W Sun, J Xue, Z Zhou, W Wang, Q Guo… - Nature cell …, 2023 - nature.com
Mitochondrial proteases are emerging as key regulators of mitochondrial plasticity and
acting as both protein quality surveillance and regulatory enzymes by performing highly …

Metabolomics of various samples advancing biomarker discovery and pathogenesis elucidation for diabetic retinopathy

X Du, L Yang, L Kong, Y Sun, K Shen, Y Cai… - Frontiers in …, 2022 - frontiersin.org
Diabetic retinopathy (DR) is a universal microvascular complication of diabetes mellitus
(DM), which is the main reason for global sight damage/loss in middle-aged and/or older …

The role and mechanisms of gut microbiota in diabetic nephropathy, diabetic retinopathy and cardiovascular diseases

Q Lv, Z Li, A Sui, X Yang, Y Han, R Yao - Frontiers in Microbiology, 2022 - frontiersin.org
Type 2 diabetes mellitus (T2DM) and T2DM-related complications [such as retinopathy,
nephropathy, and cardiovascular diseases (CVDs)] are the most prevalent metabolic …

Dual-modal nanoplatform integrated with smartphone for hierarchical diabetic detection

L Huang, Y Zhou, Y Zhu, H Su, S Yang, L Feng… - Biosensors and …, 2022 - Elsevier
On-site screening of diabetes and precise diagnosis of diabetic complications may provide a
conduit for early intervention and disease burden reduction. However, stratified metabolic …