Ventricular hypertrophy develops in response to numerous forms of cardiac stress, including
pressure or volume overload, loss of contractile mass from prior infarction, neuroendocrine …

It has recently been proposed that heart failure is a risk factor for Alzheimer′ s disease.
Decreased cerebral blood flow and neurohormonal activation due to heart failure may …

Unlike during development, blood vessels in the adult are generally thought not to require
VEGF for normal function. However, VEGF is a survival factor for many tumor vessels, and …

Current efforts in cardiac tissue engineering center around the use of scaffolds that deliver
cells to the epicardial surface. In this study, we examined the effects of fibrin glue as an …

Background—Reactive oxygen species (ROS) play an important role in the maintenance of
cardiovascular homeostasis. The present study sought to determine whether nuclear factor …

Circulating platelets contain high concentrations of TGF-β1 in their α-granules and release it
on platelet adhesion/activation. We hypothesized that uncontrolled in vitro release of platelet …

Rationale: Endoplasmic reticulum (ER) stress dysregulates ER proteostasis, which activates
the transcription factor, ATF6 (activating transcription factor 6α), an inducer of genes that …

Catecholamines and α 1-adrenergic receptors (α 1-ARs) cause cardiac hypertrophy in
cultured myocytes and transgenic mice, but heart size is normal in single KOs of the main α …

Ventricular myocyte hypertrophy is an important compensatory growth response to pressure
overload. However, pathophysiological cardiac hypertrophy is accompanied by reactive …

α1-adrenergic receptors (ARs) play a major role in blood pressure regulation. The three α1-
AR subtypes (A/C, B, and D) stimulate contraction of isolated arteries, but it is uncertain how …